Donor PNPLA3 rs738409 genotype is a risk factor for graft steatosis. A post-transplant biopsy-based study
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
29396131
DOI
10.1016/j.dld.2017.12.030
PII: S1590-8658(18)30128-2
Knihovny.cz E-resources
- Keywords
- Liver biopsy, Liver transplantation, NAFLD, PNPLA3,
- MeSH
- Adiposity genetics MeSH
- Allografts pathology MeSH
- Biopsy MeSH
- Tissue Donors MeSH
- Diabetes Mellitus epidemiology MeSH
- Adult MeSH
- Genotype MeSH
- Body Mass Index MeSH
- Liver pathology MeSH
- Polymorphism, Single Nucleotide MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipase genetics MeSH
- Membrane Proteins genetics MeSH
- Postoperative Complications genetics pathology MeSH
- Transplant Recipients MeSH
- Risk Factors MeSH
- Liver Transplantation * MeSH
- Triglycerides blood MeSH
- Fatty Liver genetics pathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- adiponutrin, human MeSH Browser
- Lipase MeSH
- Membrane Proteins MeSH
- Triglycerides MeSH
BACKGROUND & AIMS: The rs738409 c.444C > G (p.I148M) polymorphism in PNPLA3 is a major factor predisposing to non-alcoholic fatty liver disease. The aim of the study was to clarify the impact of liver and extrahepatic expression of the PNPLA3 p.148M variant on liver graft steatosis after liver transplantation. METHODS: Fat content was assessed in liver biopsies from 176 transplant recipients. During a period of 4 ± 1 years after transplantation, 17 patients developed grade 3 steatosis, 14 patients grade 2 steatosis, 56 patients grade 1 steatosis, and 89 patients grade 0 steatosis. The influence of the recipient and donor rs738409 genotype and clinical and laboratory data on liver fat content were analyzed using ordinal logistic regression. RESULTS: The PNPLA3 rs738409 CC/CG/GG genotype frequencies, respectively, were 0.494/0.449/0.057 in the graft donors and 0.545/0.330/0.125 in the graft recipients. In the multivariate analysis, the presence of the PNPLA3 c.444G allele in donor (OR 1.62; 95%CI 1.12-2.33), post-transplant BMI (OR 1.14; 95%CI 1.07-1.22), diabetes mellitus (OR 1.99; 95%CI 1.22-3.22), and serum triglycerides (OR 1.40; 95%CI 1.11-1.76) were independent risk factors for increased liver graft fat content. CONCLUSIONS: These data indicate that the liver expression of the PNPLA3 p.148M variant confers a genetic predisposition to liver graft steatosis along with nutritional status and diabetes.
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