The Interest of Women with Mayer-Rokitansky-Küster-Hauser Syndrome and Laparoscopic Vecchietti Neovagina in Uterus Transplantation
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
29751094
DOI
10.1016/j.jpag.2018.04.007
PII: S1083-3188(18)30210-9
Knihovny.cz E-resources
- Keywords
- AUFI, Absolute uterine factor infertility, Infertility, MRKH, Mayer–Rokitansky–Küster–Hauser syndrome, Neovagina, Uterus transplantation,
- MeSH
- Surgically-Created Structures MeSH
- Adult MeSH
- Mullerian Ducts abnormalities surgery MeSH
- Laparoscopy methods MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- 46, XX Disorders of Sex Development psychology surgery MeSH
- Attitude to Health MeSH
- Prospective Studies MeSH
- Organ Transplantation psychology MeSH
- Uterus transplantation MeSH
- Vagina surgery MeSH
- Congenital Abnormalities psychology surgery MeSH
- Infertility, Female psychology surgery MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
STUDY OBJECTIVE: The goal of this study was to assess a group of women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome with surgically created neovaginas in the interest of uterus transplantation (UTx) and to recruit the first group of applicants for a UTx trial. DESIGN AND SETTING: This was an original prospective study using semistructured interviews. PARTICIPANTS: A study group of 50 women with MRKH syndrome with Vecchietti neovaginas was recruited via letter of invitation. INTERVENTIONS AND MAIN OUTCOME MEASURES: Interest of MRKH women in obtaining experimental UTx for the treatment of absolute uterine factor infertility. RESULTS: A total of 50 women responded via e-mail and 31 (62% [31 of 50] of the study group) expressed serious interest in UTx after complete information about its risks and benefits was provided during the first semistructured interview. They subsequently agreed to participate in additional interviews and further examinations. Because of various reasons, only 9 women were prepared to enter our UTx trial (18% [9 of 50] of the study group). Three recipients/donors were accepted into the living donor arm and 6 into the deceased brain donor arm of the trial. CONCLUSION: Nearly two-thirds of our MRKH syndrome study group women with surgically created neovaginas were interested in UTx and motivated to undergo this method of absolute uterine factor infertility treatment. Therefore, this group of women might be approached to participate in ongoing and future UTx trials. Future studies of women with MRKH syndrome might confirm or disprove the results of our survey.
Transplant Surgery Department Institute for Clinical and Experimental Medicine Prague Czech Republic
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