Independent effect of atrial fibrillation on natriuretic peptide release
Language English Country Germany Media print-electronic
Document type Journal Article
Grant support
IKEM IN 00023001
Ministry of Health of the Czech Republic (CZ)
2018-2018
ESC Research Fellowship
PubMed
30051184
DOI
10.1007/s00392-018-1332-1
PII: 10.1007/s00392-018-1332-1
Knihovny.cz E-resources
- Keywords
- Atrial fibrillation, Atrial pressure, Heart failure with preserved ejection fraction, Natriuretic peptide,
- MeSH
- Atrial Natriuretic Factor blood MeSH
- Biomarkers blood MeSH
- Echocardiography MeSH
- Atrial Fibrillation blood diagnosis surgery MeSH
- Ventricular Function, Left physiology MeSH
- Catheter Ablation methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Follow-Up Studies MeSH
- Natriuretic Peptide, Brain blood MeSH
- Prognosis MeSH
- Disease Progression MeSH
- Prospective Studies MeSH
- Atrial Appendage diagnostic imaging MeSH
- Atrial Pressure physiology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Atrial Natriuretic Factor MeSH
- Biomarkers MeSH
- midregional pro-atrial natriuretic peptide, human MeSH Browser
- Natriuretic Peptide, Brain MeSH
BACKGROUND: We investigated whether the increase of plasma natriuretic peptides (NPs) in atrial fibrillation (AF) is independent of the effect of AF on the left atrial (LA) hemodynamics. METHODS: Hemodynamically stable patients scheduled for AF ablation underwent assessment of B-type natriuretic peptide (BNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP), echocardiography, and direct measurement of left atrial (LA) pressure. Concentrations of the NPs were compared between patients in AF (n = 31) and controls in sinus rhythm (SR; n = 31) who were matched for age, gender, heart rate, left ventricular ejection fraction, LA volume index, and directly measured mean LA pressure. Eighteen patients underwent serial measurement of NPs and LA pressure during native SR and after 20 min of pacing-induced AF. RESULTS: Compared to the patients in SR, the patients in AF had 2.6 times higher unadjusted BNP [median (inter-quartile range), 101 (63, 129) vs. 38 (26, 79) ng/L] and two times higher unadjusted MR-proANP [183 (140, 230) vs. 91 (67, 135) pmol/L; both p < 0.001]. Concentrations of both NPs correlated with mean LA pressure in the patients in SR (r = 0.75 for BNP and 0.62 for MR-proANP, both p < 0.001) but not in the patients in AF (r = 0.18 and 0.04, respectively, both p > 0.3). Both NPs increased significantly during induced AF [adjusted median (IQR) relative change, BNP: 27 (22; 40)%, MR-proANP: 75 (64; 99)%, both p < 0.001] without a significant change in the LA pressure. CONCLUSIONS: The increase of NPs in AF was independent of its effect on the LA hemodynamics.
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