Donor and recipient risk factor analysis of inferior postheart transplantation outcome in the era of durable mechanical assist devices
Language English Country Denmark Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30144327
DOI
10.1111/ctr.13390
Knihovny.cz E-resources
- Keywords
- donor characteristics, donor-recipient matching, heart transplantation, left ventricular assist device, mechanical assist device, recipient characteristics,
- MeSH
- Tissue Donors supply & distribution MeSH
- Adult MeSH
- Factor Analysis, Statistical MeSH
- Risk Assessment methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Survival Rate MeSH
- Young Adult MeSH
- Follow-Up Studies MeSH
- Heart-Assist Devices statistics & numerical data MeSH
- Postoperative Complications mortality MeSH
- Graft Survival MeSH
- Transplant Recipients statistics & numerical data MeSH
- Prognosis MeSH
- Prospective Studies MeSH
- Graft Rejection mortality MeSH
- Risk Factors MeSH
- Heart Transplantation mortality MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The study objective is to quantify the impact of donor and recipient variables on heart transplant survival in recipients with a significant proportion of implanted continuous-flow left ventricular assist devices (LVADs). This is a prospective cohort study of International Society for Heart and Lung Transplantation (ISHLT) Registry that includes all primary heart-alone transplants in adult recipients (January 2005 and June 2013, N = 15 532, 27% LVADs). Donor and recipient characteristics were assessed for association with death or graft failure within 90 days and between 90 days and 5 years after transplantation. On Cox proportional hazard model donor cause of death other than head trauma (hazard ratio [HR] 1.985, P < 0.0001), recipient congenital (HR 2.7555, P < 0.0001) and ischemic (HR 1.165, P = 0.0383) vs dilated etiology and female donor heart transplanted into male recipient (HR 1.207, P = 0.0354) were predictors of death or graft failure within 90 days. Between 90 days and 5 years, donor cigarette use (HR 1.232, P = 0.0001), recipient cigarette use (HR 1.193, P = 0.0003), diabetes (HR 1.159, P = 0.0050), arterial hypertension (HR 1.129, P = 0.0115), and ischemic vs dilative cardiomyopathy had an increased probability of death or graft failure.
Department of Cardiac Surgery Institute for Clinical and Experimental Medicine Prague Czech Republic
Department of Cardiology Freeman Hospital Newcastle upon Tyne UK
Department of Cardiothoracic Surgery Freeman Hospital Newcastle upon Tyne UK
Institute of Genetic Medicine Newcastle University Newcastle upon Tyne UK
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