Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30165271
DOI
10.1016/j.pscychresns.2018.08.012
PII: S0925-4927(18)30065-9
Knihovny.cz E-resources
- Keywords
- Emotional faces, Fear, IAPS, International Affective Picture System, Social phobia, fMRI,
- MeSH
- Affect physiology MeSH
- Amygdala diagnostic imaging physiopathology MeSH
- Adult MeSH
- Emotions physiology MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods MeSH
- Brain Mapping methods MeSH
- Young Adult MeSH
- Phobia, Social diagnostic imaging physiopathology psychology MeSH
- Social Behavior * MeSH
- Fear physiology psychology MeSH
- Photic Stimulation methods MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Social anxiety disorder (SAD) is characterized by exaggerated amygdala reactivity in response to symptom provocation, but it is unclear if such hyper-reactivity is elicited by disorder-specific challenges only or characterizes reactions to aversive stimuli in general. Here, using functional magnetic resonance imaging in 14 patients with SAD, as compared to 12 healthy controls, we found that amygdala hyper-reactivity is confined to disorder-relevant social stimulation. SAD patients displayed increased amygdala reactivity to fearful as compared to neutral facial pictures, but not in response to generally aversive but mainly non-social stimulation when compared to neutral pictorial stimuli taken from the International Affective Picture System. The increased amygdala reactivity was not mediated by an altered prefrontal inhibition among SAD patients as compared to controls, suggesting increased bottom-up processes rather than attenuated top-down control. In conclusion, the enhanced amygdala reactivity in SAD seems specific to socially relevant stimuli rather than aversive stimuli in general.
Department of Clinical Neuroscience Karolinska Institute Nobels väg 9 Stockholm Sweden
Department of Psychology Stockholm University Stockholm Sweden
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