Neural Stem Cells Derived from Human-Induced Pluripotent Stem Cells and Their Use in Models of CNS Injury
Language English Country Germany Media print
Document type Journal Article
- Keywords
- Induced pluripotent stem cells, Neural stem cells, Neuronal differentiation, Spinal cord injury, Stroke,
- MeSH
- Cell Differentiation * MeSH
- Stroke pathology therapy MeSH
- Induced Pluripotent Stem Cells cytology MeSH
- Humans MeSH
- Models, Neurological * MeSH
- Neural Stem Cells cytology MeSH
- Spinal Cord Injuries pathology therapy MeSH
- Cellular Reprogramming MeSH
- Transcription Factors metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Transcription Factors MeSH
Induced pluripotent stem (iPS) cells are derived from differentiated cells by different reprogramming techniques, by introducing specific transcription factors responsible for pluripotency. Induced pluripotent stem cells can serve as an excellent source for differentiated neural stem/progenitor cells (NSCs/NPs). Several methods and protocols are utilized to create a robust number of NSCs/NPs without jeopardizing the safety issues required for in vivo applications. A variety of disease-specific iPS cells have been used to study nervous system diseases. In this chapter, we will focus on some of the derivation and differentiation approaches and the application of iPS-NPs in the treatment of spinal cord injury and stroke.
2nd Faculty of Medicine Charles University Prague Czech Republic
Institute of Experimental Medicine ASCR Prague Czech Republic
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