Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30458190
DOI
10.1016/j.steroids.2018.11.007
PII: S0039-128X(18)30211-3
Knihovny.cz E-resources
- Keywords
- Cyclodextrins, Ecdysterones, Inclusion complexes, NMR spectroscopy,
- MeSH
- Biological Availability MeSH
- Cyclodextrins chemistry MeSH
- Ecdysterone chemistry isolation & purification pharmacokinetics MeSH
- Magnetic Resonance Spectroscopy MeSH
- Molecular Conformation MeSH
- Solubility MeSH
- Silene chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cyclodextrins MeSH
- Ecdysterone MeSH
20-Hydroxyecdysterone - (2β,3β,5β,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one was isolated in satisfactory yield using ethanol extraction from the aerial part of Silene wolgensis (Hornem.) Otth; sometimes Silene wolgensis (Willd.) Bess. ex Spreng. The complexation of the phytoecdysteroid with β-cyclodextrin was studied by NMR spectroscopy. By studying the changes in chemical shifts of protons of substrates and receptors it was found that ecdysterone interacts with cyclodextrins to form supramolecular inclusion complexes of stoichiometric composition of 1:1 or 1:2. Ecdysterone-β-cyclodextrin complexes exhibit 100 times higher solubility in water than the parent compound.
International Research and Production Holding Phytochemistry 470000 Karaganda Kazakhstan
University of Chemistry and Technology Prague 166 28 Praha 6 Czech Republic
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