Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)
Status PubMed-not-MEDLINE Language English Country England, Great Britain Media print
Document type Journal Article
PubMed
30601480
DOI
10.1039/c8cc08716d
Knihovny.cz E-resources
- Publication type
- Journal Article MeSH
A preloaded resin consisting of a thalidomide moiety and an ethylene-oxy linker allows the simple and fast formation of PROTACs. The feasibility of the procedure was illustrated by conjugating different protein kinase inhibitors. The biological functionality of an ibrutinib-like conjugate was then confirmed by a cellular experiment.
References provided by Crossref.org
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