Chyawanprash (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging. Chyawanprash is formulated by processing around 50 medicinal herbs and their extracts, including the prime ingredient, Amla (Indian gooseberry), which is the world's richest source of vitamin C. Chyawanprash preparation involves preparing a decoction of herbs, followed by dried extract preparation, subsequent mixture with honey, and addition of aromatic herb powders (namely clove, cardamom, and cinnamon) as standard. The finished product has a fruit jam-like consistency, and a sweet, sour, and spicy flavor. Scientific exploration of CP is warranted to understand its therapeutic efficacy. Scattered information exploring the therapeutic potential of CP is available, and there is a need to assemble it. Thus, an effort was made to compile the scattered information from ancient Ayurvedic texts and treatises, along with ethnobotanical, ethnopharmacological, and scientifically validated literature, that highlight the role of CP in therapeutics. Citations relevant to the topic were screened.

Central Ayurveda Research Institute for Drug Development Ministry of AYUSH Government of India 4 CN Block Sector 5 Bidhannagar Kolkata 700091 India

Department of Biotechnology MMEC Maharishi Markandeshwar Mullana Ambala 133207 India

Department of Chemistry Faculty of Science University of Hradec Králové Rokitanskeho 62 50003 Hradec Králové Czech Republic

Department of Pharmacology Kota College of Pharmacy Kota Rajasthan 324005 India

Department of Rasashastra and Bhaishajya Kalpana All India Institute of Ayurveda New Delhi 110076 India

Faculty of Medicine University of Porto Alameda Prof Hernani Monteiro 4200 319 Porto Portugal

Institute for research and Innovation in Heath University of Porto Rua Alfredo Allen 4200 135 Porto Portugal

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Parle M., Bansal N. Traditional medicinal formulation, Chyawanprash—A review. Ind. J. Tradit. Knowl. 2006;5:484–488.

Trivedi R.P. Bhaishajya Kalpana. Dhanvantari Karyalaya; Aligarh, India: 1951. p. 260.

Sharma R.K., Charak S. Chikitsa Sathanam. Volume II. Motilal Banarasidas; Varanasi, India: 1954. p. 4.

Sharma P.V. Caraka Samhita. second ed. Volume II. Chaukhamba Orientalia; Varanasi, India: 1992. pp. 3–10.

Ram G., Amrit S., Khem R. Sri Krishan Das. Sri Vanketshwar Steam Press; Bombay, India: 1948. p. 3.

Mehta P.M. Realms of Ayurveda by Pandit Shiv Sharma. Arnold-Heinemann Publishers; New Delhi, India: 1979. History of Indian Medicine.66p

Rao R.S.K. Encyclopaedia of Indian Medicine-Historical Perspective. Volume I. Popular Prakashan; Bombay, India: 1985. 25p

Panda H. Handbook on Ayurvedic Medicines with Formulae, Processes and Their Uses. National Institute of Industrial Research; New Delhi, India: 2002. p. 10.

Bates D. Knowledge and the Scholarly Medical Traditions. Cambridge University Press; Cambridge, MA, USA: 1995. 325p

Anonymous. The Ayurvedic Formulary of India. Ministry of Health & Family Welfare; New Delhi, India: 2003. p. 37.

Balakrishna A., Srivastava A., Mishra R.K., Patel S.P., Vashishtha R.K., Singh A., Jadon V., Saxena P. Astavarga plants—Threatened medicinal herbs of north-west Himalaya. Int. J. Med. Arom. Plants. 2012;2:661–676.

Panigrahi J., Gantait S., Patel I.C. Concurrent production and relative quantification of vasicinone from in vivo and in vitro plant parts of Malabar nut (Adhatoda vasica Nees) Biotechnology. 2017;1:280. doi: 10.1007/s13205-017-0882-7. PubMed DOI PMC

Nair C.J., Ahamad S., Khan W., Anjum V., Mathur R. Development and validation of high-performance thin-layer chromatography method for simultaneous determination of polyphenolic compounds in medicinal plants. Pharmacogn. Res. 2017;9:S67. PubMed PMC

Ismail S., Maulidiani M., Akhtar M., Abas F., Ismail I., Khatib A., Ali N., Shaari K. Discriminative analysis of different grades of gaharu (Aquilaria malaccensis Lamk.) via 1H-NMR-based metabolomics using PLS-DA and random forests classification models. Molecules. 2017;22:1612. doi: 10.3390/molecules22101612. PubMed DOI PMC

Rathod Jaimik D., Pathak Nimish L., Patel Ritesh G., Jivani N.P., Bhatt Nayna M. Phytopharmacological properties of Bambusa arundinacea as a potential medicinal tree: An Overview. J. Appl. Pharm. Sci. 2011;1:27–31.

Nayak P., Thirunavoukkarasu M. A review of the plant Boerhaavia diffusa: Its chemistry, pharmacology and therapeutical potential. J. Phytopharmacol. 2016;5:83–92.

Kumar S., Kumari R. Cinnamomum: Review article of essential oil compounds, ethnobotany, antifungal and antibacterial effects. Open Access J. Sci. 2019;3:13–16.

Saha S. Honey-The natural sweetener become a promising alternative therapeutic: A review. South Ind. J. Biol. Sci. 2015;1:103–114.

Chen C.C., Chen Y., Hsi Y.T., Chang C.S., Huang L.F., Ho C.T., Way T.D., Kao J.Y. Chemical constituents and anticancer activity of Curcuma zedoaria roscoe essential oil against non-small cell lung carcinoma cells in vitro and in vivo. J. Agric. Food Chem. 2013;18:11418–11427. doi: 10.1021/jf4026184. PubMed DOI

Ju Y., Xiao B. Chemical constituents of Cyperus rotundus L. and their inhibitory effects on uterine fibroids. Afr. Health Sci. 2016;16:1000–1006. doi: 10.4314/ahs.v16i4.16. PubMed DOI PMC

Govindarajan R.S., Rastogi M., Vijayakumar A.K.S., Rawat A., Shirwaikar S., Mehrotra P.P. Studies on antioxidant activities of Desmodium gangetium. Biol. Pharm. Bull. 2003;26:1424–1427. doi: 10.1248/bpb.26.1424. PubMed DOI

Masoumi-Ardakani Y., Mandegary A., Esmaeilpour K., Najafipour H., Sharififar F., Pakravanan M., Ghazvini H. Chemical composition, anticonvulsant activity, and toxicity of essential oil and methanolic extract of Elettaria cardamomum. Planta Med. 2016;82:1482–1486. doi: 10.1055/s-0042-106971. PubMed DOI

Jain R., Pandey R., Mahant R.N., Rathore D.S. A review on medicinal importance of Emblica officinalis. Int. J. Pharm. Sci. Res. 2015;1:72.

Moronkola D.O., Ogunwande I.A., Başer K.H., Ozek T., Ozek G. Essential oil composition of Gmelina arborea Roxb., Verbenaceae, from Nigeria. J. Essent. Oil Res. 2009;1:264–266. doi: 10.1080/10412905.2009.9700165. DOI

Huo Y., Shi H.M., Wang M.Y., Li X.B. Chemical constituents and pharmacological properties of Radix Inulae. Die Pharm. 2008;1:699–703. PubMed

Bawra B., Dixit M., Chauhan N.S., Dixit V.K., Saraf D.K. Leptadenia reticulata a rasayana herbs: A review. Asian J. Plant Sci. 2010;9:314. doi: 10.3923/ajps.2010.314.319. DOI

Dhingra A.K., Chopra B., Mittal S.K. Martynia annua L.: A review on Its ethnobotany, phytochemical and pharmacological profile. J. Pharmacogn. Phytochem. 2013;1:1.

Teh S.S., Ee G.C., Mah S.H. Chemical Constituents and New Xanthone Derivatives from Mesua ferrea and Mesua congestiflora. Asian J. Chem. 2013;1:25. doi: 10.14233/ajchem.2013.15615. PubMed DOI PMC

Paudel K.R., Panth N. Phytochemical profile and biological activity of Nelumbo nucifera. Evid. Based Complement. Altern. Med. 2015;2015 doi: 10.1155/2015/789124. PubMed DOI PMC

Deka D.C., Kumar V., Prasad C., Kumar K., Gogoi B.J., Singh L., Srivastava R.B. Oroxylum indicum—A medicinal plant of North East India: An overview of its nutritional, remedial, and prophylactic properties. J. Appl. Pharm. Sci. 2013;3:S104–S112.

Fursule R.A., Patil S.D. Hepatoprotective and antioxidant activity of Phaseolus trilobus, Ait on bile duct ligation induced liver fibrosis in rats. J. Ethnopharmacol. 2010;16:416–419. doi: 10.1016/j.jep.2010.04.021. PubMed DOI

Bagalkotkar G., Sagineedu S.R., Saad M.S., Stanslas J. Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: A review. J. Pharm. Pharmacol. 2006;58:1559–1570. doi: 10.1211/jpp.58.12.0001. PubMed DOI

Choudhary N., Singh V. Piper longum: A review of its phytochemicals and their network pharmacological evaluation. bioRxiv. 2017;1:169763. PubMed PMC

Bibi Y., Zia M., Qayyum A. An overview of Pistacia integerrima a medicinal plant species: Ethnobotany, biological activities and phytochemistry. Pak. J. Pharm. Sci. 2015;1:1009–1013. PubMed

Mali P.Y. Premna integrifolia L.: A review of its biodiversity, traditional uses and phytochemistry. Ancient Sci. Life. 2015;35:4. doi: 10.4103/0257-7941.165624. PubMed DOI PMC

Bulle S., Reddyvari H., Nallanchakravarthula V., Vaddi D.R. Therapeutic potential of Pterocarpus santalinus L.: An update. Pharmacogn. Rev. 2016;10:43. PubMed PMC

Kuo P.C., Lin M.C., Chen G.F., Yiu T.J., Tzen J.T. Identification of methanol-soluble compounds in sesame and evaluation of antioxidant potential of its lignans. J. Agric Food Chem. 2011;10:3214–3219. doi: 10.1021/jf104311g. PubMed DOI

Jain A., Choubey S., Singour P.K., Rajak H., Pawar R.S. Sida cordifolia (linn)—An overview. J. Appl. Pharm. Sci. 2011;1:23–31.

Sharma V., Hem K., Seth A., Maurya S.K. Solanum indicum Linn.: An ethnopharmacological, phytochemical and pharmacological review. Curr. Res. J. Pharm. Allied Sci. 2017;1:1–9.

Preet R., Gupta R.C. HPTLC Analysis of Solanum xanthocarpum Schrad. and Wendl., a Siddha Medicinal Herb. Adv. Pharmacol. Sci. 2018;2018 doi: 10.1155/2018/8546306. PubMed DOI PMC

Nag M., Mukherjee P.K., Chanda J., Biswas R., Harwansh R.K., Al-Dhabi N.A., Duraipandiyan V. Plant developed analytical profile of Stereospermum suaveolens in Indian Traditional Knowledge. Ind. J. Tradit. Knowl. 2015;14:590–594.

Sridhar C., Krishnaraju A.V., Subbaraju G.V. Antiinflammatory constituents of Teramnus labialis. Ind. J. Pharm. Sci. 2006;68:111.

Upadhyay A., Agrahari P., Singh D.K. A review on the pharmacological aspects of Terminalia chebula. Int. J. Pharmacol. 2014;15:289–298.

Joshi G., Kaur R. Tinospora cordifolia: A phytopharmacological review. Int. J. Pharm. Sci. Res. 2016;1:890.

Chhatre S., Nesari T., Somani G., Kanchan D., Sathaye S. Phytopharmacological overview of Tribulus terrestris. Pharmacog. Rev. 2014;8:45. doi: 10.4103/0973-7847.125530. PubMed DOI PMC

Rahman M.M., Gibbons S., Gray A.I. Isoflavanones from Uraria picta and their antimicrobial activity. Phytochemistry. 2007;1:1692–1697. doi: 10.1016/j.phytochem.2007.04.015. PubMed DOI

Nassiri-Asl M., Hosseinzadeh H. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive constituents: An update. Phytother. Res. 2016;30:1392–1403. doi: 10.1002/ptr.5644. PubMed DOI

Ahmad N., Saleem M. Studying heating effects on desi ghee obtained from buffalo milk using fluorescence spectroscopy. PLoS ONE. 2018;13:e0197340. doi: 10.1371/journal.pone.0197340. PubMed DOI PMC

Wang J., Li Q.X. Chemical composition, characterization, and differentiation of honey botanical and geographical origins. Adv. Food Nutr. Res. 2011;62:89–137. PubMed

Alok S., Jain S.K., Verma A., Kumar M., Mahor A., Sabharwal M. Plant profile, phytochemistry and pharmacology of Asparagus racemosus (Shatavari): A review. Asian Pac. J. Trop. Dis. 2013;1:242–251. doi: 10.1016/S2222-1808(13)60049-3. DOI

Galani V.J., Patel D.M. A comprehensive phytopharmacological review of Dioscorea bulbifera Linn. Int. J. Environ. Sci. Nat. Resour. 2017;4:1.

Meira M., Silva E.P., David J.M., David J.P. Review of the genus Ipomoea: Traditional uses, chemistry and biological activities. Rev. Bras. Farmacogn. 2012;22:682–713. doi: 10.1590/S0102-695X2012005000025. DOI

Uddin Q., Samiulla L., Singh V.K., Jamil S.S. Phytochemical and pharmacological profile of Withania somnifera Dunal: A review. J. Appl. Pharm. Sci. 2012;2:170–175.

Sharma R., Prajapati P.K. Nanotechnology in medicine: Leads from Ayurveda. J. Pharm. Bioallied Sci. 2016;8:80–81. doi: 10.4103/0975-7406.171730. PubMed DOI PMC

Uddin M.A., Shahinuzzaman M., Rana M.S., Yaakob Z. Study of chemical composition and medicinal properties of volatile oil from clove buds (Eugenia caryophyllus) Int. J. Pharm. Sci. Res. 2017;1:895.

Rastogi S., Bala S., Govindrajan R., Rawat A.K., Mehrotra S. Quantitative analysis of Chyawanprash: A well-known Ayurvedic Formulation. Ind. J. Pharm. Sci. 2004;66:753–757.

Kumar A., Kaur P., Rinwa P. Evaluation of morphological, phytochemical and physicochemical properties of Indian polyherbal formulation, Chyawanprash for quality evaluation. Asian J. Pharm. Educ. Res. 2012;1:121–140.

Wagh V.D., Patil S.V., Surana S.J., Wagh K.V. Medicinal plants used in preparation of polyherbal ayurvedic formulation Chyawanprash. J. Med. Plants Res. 2013;7:2801–2814.

Virk J.K., Gupta V., Kumar S., Singh R., Bansal P. Ashtawarga plants—Suffering a triple standardization syndrome. J. Tradit. Complement. Med. 2017;7:392–399. doi: 10.1016/j.jtcme.2016.12.011. PubMed DOI PMC

Dalai S.K., Dashora M.S., Dwivedi L. Numerical v/s quantitative variations in ingredients of Chyawanprash—Limiting factor for the SOP. Ind. J. Tradit. Knowl. 2007;6:426–428.

Anonymous. Ayurved Sarsangarah. Shree Baidyanath Ayurved Bhawan Pvt Ltd.; Calcutta, India: 1965. p. 540.

Srikanta Murthy K.R., Sarngadhar Samhita A. Treatise on Ayurveda. Chaukhambha Orientalia; Varanasi, India: 1995. 111p

Rastantar S., Sidh P. Sangrah. Volume 1. Krishan Gopal Ayurved Bhawan; Ajmer, India: 1961. 779p

Shah N.C. Bharat Bhaishjya Ratnakar. Volume II. B Jain Publishers Private Ltd.; New Delhi, India: 1999. 164p

Anonymous. Handbook of Domestic Medicine and Common Ayurvedic Remedies. Central Council for Research in Indian Medicine and Homeopathy, Ministry of Health & Family Welfare; New Delhi, India: 1978. 380p

Sharma R.D., Malviya M.M. Chyawanprash se Kayakalpavat Labh Kyon Nahin? Ayurved Mahasammelan Patrika. All India Ayurvedic Congress; New Delhi, India: 1971. 399p

Anonymous. Ayurvediya Aushadiyan & Samanaya Gharelu Upchar, Kendriya Ayurveda & Sidh Anusandhan Parishad. Ministry of Health & Family Welfare; New Delhi, India: 1988. 40p

Ghosh A., Laloo D., Singh N.K. Comparative estimation and chemical standardization of new and old sample of Chyawanprash. Int. J. Pharm. Pharm. Sci. 2013;5:801–804.

Ojha J.K. Chyawanprash from Vedic and Genomic Era. Chaukhamba Sanskrit Pratishtha; New Delhi, India: 2003.

Anonymous. Ayurvedic Pharmacopeia of India Part–II (Formulation) 1st ed. Volume I Department of AYUSH; New Delhi, India: 2007.

Govindarajan R., Singh D.P., Rawat A.K. High pressure liquid chromatographic method for the quantification of phenolics in chyavanprash. J. Pharm. Biomed. Anal. 2007;43:527–532. doi: 10.1016/j.jpba.2006.08.005. PubMed DOI

Wealth of India, Raw Materials Series. Volume III. Publications and Information Directorate; New Delhi, India: 1989. 168p

Tarwadi K., Agte V. Antioxidant and micronutrient potential of common fruits available in the Indian subcontinent. Int. J. Food Sci. Nutr. 2007;58:341–349. doi: 10.1080/09637480701243905. PubMed DOI

Anand N. Comprehensive Medicinal Chemistry. Volume I. PD Pergamon Press; New York, NY, USA: 1990. 113p

Anonymous. Pharmacopoeial Standards for Ayurvedic Formulation. CCRIMH. 1976;15:87.

Katiyar C.K. Eastern Pharmacist. Volume 4. Pamposh Publications; New Delhi, India: 1995. 454p XXXVIII.

Narayanan M.N. Eastern Pharmacist. Volume 4. Pamposh Publications; New Delhi, India: 1995. 451p XXXVIII.

Shishoo C.J., Shah S.A., Rathod I.S., Patel S.G. Determination of Vitamin C content of Phyllanthus emblica and Chyawanprash. Ind. J. Pharm. Sci. 1997;59:268–271.

Bhandari C.R. Vanoshadhi-Chandrodaya. Volume I. Gyan Mandir; Bhanpura, India: 1938. 112p

Manjunatha S., Jaryal A.K., Bijlani R.L., Sachdeva U., Gupta S.K. Effect of Chyawanprash and vitamin C on glucose tolerance and lipoprotein profile. Ind. J. Physiol. Pharmacol. 2001;45:71–79. PubMed

Agte V.V., Mengale S.S., Akkalkotkar M., Paknikar K.M., Chiplonkar S.A. Antioxidant and trace element potential of Chyavanpraash and some Ayurvedic preparations. Ind. J. Tradit. Knowl. 2003;2:215–223.

Elliot J.G. Application of antioxidant vitamins in foods and beverages. Food Technol. 1999;53:46–48.

Das L., Bhaumik E., Raychaudhuri U., Chakraborty R. Role of nutraceuticals in human health. J. Food Sci. Technol. 2011;49:173–183. doi: 10.1007/s13197-011-0269-4. PubMed DOI PMC

Kumar A., Rinwa P., Kaur P. Chyawanprash: A wonder Indian Rasayana from Ayurveda to Modern Age. Crit. Rev. Pharm. Sci. 2012;1:1–8.

Datta Goutam K., Debnath P.K. Stress Adaptation in Ayurveda by Immunomodulatory Rasayana; Proceedings of the National Seminar on Rasayana, CCRAS; New Delhi, India. 8–10 March 1999; pp. 60–75.

Ernst W. Plural Medicine, Tradition and Modernity, 1800–2000. Routledge; London, UK: New York, NY, USA: 2002. 187p

Nilakash S., Jonnalagadda V.G., Chawda M.B., Thakur K.S., Vahalia M.K., Shitut S.S. Acute and Sub-chronic Toxicity (90-Day) Study of Swamala in Wistar Rats. Pharm. Sci. 2014;20:52–60.

Handa S.S., Sharma A., Chakraborti K.K. Natural products and plants as liver protecting drugs. Fitotherapy. 1986;57:307–321.

Jose J.K., Kuttan R. Hepatoprotective activity of Emblica officinalis and Chyawanprash. J. Ethnopharmacol. 2000;72:135–140. doi: 10.1016/S0378-8741(00)00219-1. PubMed DOI

Roy A.K., Dhir H., Sharma A., Talukder G. Phylanthusemblica fruit extract and ascorbic acid modify hepatotoxic and renotoxic effects of metals in mice. Int. J. Pharmacogn. 1991;44:55–60.

Gulati R.K., Agarwal S., Agarwal S.S. Hepatoprotective studies on Phyllanthus emblica Linn. and quercetin. Ind. J. Exp. Biol. 1995;33:261–268. PubMed

Sharma P.V. Dravayagun Vigyan. Volume II. Chaukhamba Bharati Academy; Varanasi, India: 2003. 535p

Trikam Y. Dravayagunvigyanam. Shree Sharma Ayurved Mandir; Datiya, India: 1979. 465p

Chunekar K.C. Bhav Prakash Nighantu. Chaukhambha Bharati academy; Varanasi, India: 2002. 788p

Tripathi R.D. Ashthangsangrah. Chaukhambha Sanskrit Pristhan; New Delhi, India: 2003. 106p

Ojha J.K., Khanna N.N., Bajpay H.S., Sharma N. A clinical study on Chyawanprash as an adjuvant in the treatment of pulmonary tuberculosis. J. Res. Ind. Med. 1975;10:11–14.

Ojha J.K., Bajpai H.S., Sharma P.V., Khanna N.N., Shukla P.K., Sharma T.N. Chyawanprash as an anabolic agent; An experimental study (preliminary work) J. Res. Ind. Med. 1973;8:11–14.

Debnath P.K., Chattopadhyay J., Mitra A., Adhikari A., Alam M.S., Bandopadhyay S.K., Hazra J. Adjunct therapy of Ayurvedic medicine with anti-tubercular drugs on the therapeutic management of pulmonary tuberculosis. J. Ayurveda Integr. Med. 2012;3:141–149. doi: 10.4103/0975-9476.100180. PubMed DOI PMC

Sharma P.V. Clinical Uses of Medicinal Plants. Chaukhambha Visvabharati; Varanasi, India: 1996. 33p

Mishra L.C. Scientific Basis for Ayurvedic Therapies. CRC Press; New York, NY, USA: 2003. 70p

Liu R.H. Potential synergy of phytochemicals in cancer prevention: Mechanism of action. J. Nutr. 2004;134:3479–3485. doi: 10.1093/jn/134.12.3479S. PubMed DOI

Govindarajan R., Vijayakumar M., Pushpangadan P. Antioxidant approach to disease management and the role of ‘Rasayana’ herbs of Ayurveda. J. Ethnopharmacol. 2005;99:165–178. doi: 10.1016/j.jep.2005.02.035. PubMed DOI

Jeena K.J., Kuttan R. Antioxidant activity of Emblica officinalis. J. Clin. Biochem. Nutr. 1995;19:63.

Kumar A., Kaur P., Rinwa P. Comparative study of various marketed brands of Indian Chyawanprash for their anti-anxiety and anti-oxidant potential. Int. J. Pharm. Res. Biosci. 2012;1:296–310.

Khopde S.M., Priyadarsini K.I., Mohan H., Gawandi V.B., Satav J.G., Yakhmi J.V., Banavaliker M.M., Biyani M.K., Mittal J.P. Characterizing the antioxidant activity of Amla (Phyllanthus emblica) extract. Curr. Sci. 2001;81:185–190.

Kumar G.S., Nayakaa H., Dharmesha S.M., Salimatha P.V. Free and bound phenolic antioxidants in amla (Emblica officinalis) and turmeric (Curcuma longa) J. Food Compos. Anal. 2006;19:446–452. doi: 10.1016/j.jfca.2005.12.015. DOI

Kasar R.P., Laddha K.S., Chaudhary J., Shukla A. Development of quality control methods for poly herbal formulation, Chyawanprash. Nat. Prod. Radian. 2006;5:33–41.

Mehrotra S., Rawat A.K., Singh S. Standardization of popular ayurvedic adaptogenic preparation “Chyawanprash” and ethnokotary of its ingredients. Ethnobotany. 1995;7:1–15.

Yadav J.S., Thakur S., Chadha P. Chyawanprash Awaleha: A genoprotective agent for Bidi smokers. Int. J. Hum. Genet. 2003;3:33–38. doi: 10.1080/09723757.2003.11885825. DOI

Middha A., Purohit S. Determination of Free Radical Scavenging activity in Herbal Supplement: Chyawanprash. Int. J. Drug Dev. Res. 2011;3:328–333.

Sur T.K., Pandit S., Mukherjee R., Debnath P.K., Bandopadhyay S.K., Bhattacharya D. Effect of Sonachandi Chyawanprash and Chyawanprash Plus, two herbal formulations on immunomodulation. Nepal Med. Coll. J. 2004;6:126–128. PubMed

Bhattacharya S.K., Bhattacharya A., Sairam K., Ghosal S. Effect of bioactive tannoid principles of Emblicaofficinalison ischemia reperfusion-induced oxidative stress in rat heart. Phytomedicine. 2002;9:171–174. doi: 10.1078/0944-7113-00090. PubMed DOI

Mirunalini S., Vaithiyanathan V., Krishnaveni M. Amla: A novel Ayurvedic herb as a functional food for health benefits—A mini review. Int. J. Pharm. Pharm. Sci. 2013;5:1–4.

Singh V.K., Palbag S., Singh N.K. Comparative evaluation of furfural in branded and local honey sample by UV spectroscopy. Int. J. Pharm. Pharm. Sci. Res. 2012;2:95–96.

Shah R., Kathad H., Sheth R., Sheth N. In vitro antioxidant activity of roots of Tephrosia purpurea Linn. Int. J. Pharm. Pharm. Sci. 2010;2:30–33.

Gupta A., Kumar S., Dole S., Deshpande S., Deshpande V., Singh S., Sasibhushan V. Evaluation of Cyavanaprāśa on health and immunity related parameters in healthy children: A two arm, randomized, open labeled, prospective, multicenter, clinical study. Ancient Sci. Life. 2017;36:141–150. doi: 10.4103/asl.ASL_8_17. PubMed DOI PMC

Sastry J.L.N., Gupta A., Brindavanam N.B., Kanjilal S., Kumar S., Setia M., Vedula S., Srivastava R. Quantification of immunity status of Dabur chyawanprash—A review part-1 (experimental studies) Ind. J. Appl. Res. 2014;4:20–24. doi: 10.15373/2249555X/FEB2014/131. DOI

Sastry J.L.N., Gupta A., Brindavanam N.B., Kanjilal S., Kumar S., Setia M., Vedula S., Srivastava R. Quantification of immunity status of Dabur chyawanprash—A review part-2 (clinical studies) Ind. J. Appl. Res. 2014;4:205–211. doi: 10.15373/2249555X/MAR2014/61. DOI

Bansal N., Parle M. Beneficial effect of chyawanprash on cognitive function in aged mice. Pharm. Biol. 2011;49:2–8. doi: 10.3109/13880209.2010.489904. PubMed DOI

Sailesh K.S., Archana R., Mishra S., Symphoria Mukkadan J.K. Chyawanprash on cognitive, autonomic, and repiratory parameters in college students. Int. J. Res. Ayurveda Pharm. 2014;5:435–438.

Parle M., Bansal N. Antiamnesic Activity of an Ayurvedic Formulation Chyawanprash in Mice. Evid. Based Complement. Altern. Med. 2011;2011 doi: 10.1093/ecam/neq021. PubMed DOI PMC

Parle M., Dhingra D. Ascorbic acid: A promising memory enhancer in mice. J. Pharmacol. Sci. 2003;93:129–135. doi: 10.1254/jphs.93.129. PubMed DOI

Vasudevan M., Parle M. Effect of Anwala Churna (Emblica officinalis GAERTN): An ayurvedic preparation on memory deficit rats. Yakugaku Zasshi. 2007;127:1701–1707. doi: 10.1248/yakushi.127.1701. PubMed DOI

Thakur C.P., Thakur B., Sinha P.K., Sinha S.K. The Ayurvedic medicines Haritaki, Amla and Bahira reduce cholesterol induced atherosclerosis in rabbits. Int. J. Cardiol. 1988;21:167. doi: 10.1016/0167-5273(88)90219-7. PubMed DOI

Hashem-Dabaghian F., Ziaee M., Ghaffari S., Nabati F., Kianbakht S. A systematic review on the cardiovascular pharmacology of Emblica officinalis Gaertn. J. Cardiovasc. Thorac. Res. 2018;10:118–128. doi: 10.15171/jcvtr.2018.20. PubMed DOI PMC

Nimbal S.K., Koti B.C. Cardio protective Effect of Boerhaavia diffusa against Doxorubicin-induced myocardial toxicity in Albino Rats. Sch. Acad. J. Biosci. 2016;4:171–178.

Sharma P.V. Cakradatta: A Treatise on Principles and Practices of Ayurvedic Medicine. Chaukhambha Orientalia; Varanasi, India: 1954. 129p

Shastri A.D. BhaishjyaRatnavali. Chaukhambha Sanskrit Bhawan; Varanasi, India: 1996. 286p

Verma M.D., Singh R.H., Upadpa K.N. Physiological, endocrine and metabolic studies on the effect of rasayana therapy in aged persons. J. Res. Ind. Med. 1973;8:1–10.

Durg S., Shivaram S.B., Bavage S. Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis. Phytomedicine. 2018;50:247–256. doi: 10.1016/j.phymed.2017.11.011. PubMed DOI

Chauhan N.S., Sharma V., Dixit V.K., Thakur M. A review on plants used for improvement of sexual performance and virility. Biomed. Res. Int. 2014;2014:868062. doi: 10.1155/2014/868062. PubMed DOI PMC

Jagetia G.C., Baliga M.S. The evaluation of the radioprotective effect of chyavanaprasha (an ayurvedic rasayana drug) in mice exposed to lethal dose of gamma-radiation: A preliminary study. Phytother. Res. 2004;18:14–18. doi: 10.1002/ptr.1298. PubMed DOI

Uma A.N., Kotasthane D.S. A Cytogenetic Study on the Efficacy of Chyawanprash Awaleha as an Antioxidant in Oral Premalignant Cancer. J. Oral Oncol. 2014;2014:864230. doi: 10.1155/2014/864230. DOI

Ghosh A., Sharma A., Talukder G. Comparison of the protection afforded by crude extract of Phyllanthus emblica fruit and an equivalent amount of synthetic ascorbic acid against the cytotoxic effect of cesium chloride in mice. Int. J. Pharmacog. 1993;31:116–120. doi: 10.3109/13880209309082927. DOI

Hoda Q., Sinha S.P. Protective role of ascorbic acid and vitamin B-complex against pesticide-induced clastogeny in bone marrow cells of mice. Int. J. Vitam. Nutr. Res. 1991;61:155–158. PubMed

Alam M., Varadrarajan T.V., Venkatbushna D.D. Some studies on Chyawanprash preparation and standardization. J. Res. Ind. Med. Yoga Homeop. 1977;2:63–73.

Alam M., Joy S., Dasan K.K.S., Bhima R. Analytical and antitumour studies on Chyawanprash. J. Res. Ayur. Siddha. 1989;IX:43–49.

Jeena K.J., Kuttan G., Josely G., Kuttan R. Anti-mutagenicandanti carcinogenic activity of Emblica officinalis Gaertn. J. Clin. Biochem. Nutr. 1997;22:171.

Kohlmeier L., Simonsen N., Mottus K. Dietary modifiers of carcinogenesis. Environ. Health Perspect. 1995;103:177–178. PubMed PMC

Guilford J.M., Pezzuto J.M. Natural products as inhibitors of carcinogenesis. Expert. Opin. Investig. Drugs. 2008;17:1341–1352. doi: 10.1517/13543784.17.9.1341. PubMed DOI

Mathur R., Sharma A., Dixit V.P., Varma M. Hypolipidaemic effect of fruit juice of Emblica officinalis in cholesterol-fed rabbits. J. Ethnopharmacol. 1996;50:61–68. doi: 10.1016/0378-8741(95)01308-3. PubMed DOI

Dalai S.K., Dwivedi L., Dadheech G., Mishra S., Sharma P. Evaluation of health promotion in elderly people through Cyavanaprasa. Ancient Sci. Life. 2005;XXIV:183–191. PubMed PMC

Kumar S., Gupta A., Ghungralekar R., Deshpande V.S. Suitability for Consumption of Chyawanprakash-A Herbal Formulation in Controlled Type II Diabetics-A Open Label Clinical Study. Altern. Integr. Med. 2017;6:230. doi: 10.4172/2327-5162.1000230. DOI

Sharma R., Amin H. Rasayana Therapy: Ayurvedic contribution to improve quality of life. World J. Pharmacol. Res. Tech. 2015;4:23–33.

Sharma R., Amin H., Prajapati P., Ruknuddin G. Therapeutic Vistas of Guduchi (Tinospora cordifolia): A medico-historical memoir. J. Res. Educ. Ind. Med. 2014;XX:113–128.

Sharma R., Kabra A., Rao M.M., Prajapati P.K. Herbal and Holistic solutions for Neurodegenerative and Depressive disorders: Leads from Ayurveda. Curr. Pharm. Des. 2018;2018:2597–2608. doi: 10.2174/1381612824666180821165741. PubMed DOI

Ernst W., editor. Plural Medicine, Tradition and Modernity, 1800–2000. Routledge; London, UK: New York, NY, USA: 2002. 272p

Takauji Y., Morino K., Miki K., Hossain M., Ayusawa D., Fujii M. Chyawanprash, a formulation of traditional Ayurvedic medicine, shows a protective effect on skin photoaging in hairless mice. J. Chin. Integr. Med. 2016;14:473–479. doi: 10.1016/S2095-4964(16)60272-8. PubMed DOI

Khan M.A., Kanjilal S., Gupta A., Ahmad S. Antimicrobial activity of sugar-based semisolid polyherbal ayurvedic formulation: Chyawanprash. Drug Dev. Ther. 2016;7:31–33.

Velpandian T., Mathur P., Sengupta S., Gupta S.K. Preventive effect of Chyavanprash against steroid induced cataract in the developing chick embryo. Phytother. Res. 1998;12:320–323. doi: 10.1002/(SICI)1099-1573(199808)12:5<320::AID-PTR297>3.0.CO;2-O. DOI

Gogate V.M. Drvyaguna Vigyan. 1st ed. Continental Prakashan; Pune, India: 1962. Emblica officinalis.350p

Deshpande S.W., Gandhi N. Drugs and Cosmetic Act 1940 And Rules 1945. Susmit Publisher; Mumbai, India: 2009.

Economic Times SRK, Dhoni, Ravi Kishan Do Wonders for Chyawanprash. [(accessed on 11 December 2018)]; Available online: http://articles.economictimes.indiatimes.com/2011–01–26/news/28429729_1_chyawanprash-market-sona-chandi-chyawanprash-ravi-kishan.

Consumer Voice Magazine Comparative Test. Chyavanprash Repairs and Rejuvenates. [(accessed on 12 December 2018)]; Available online: http://consumeradvice.in/Download/Chyavanprash.pdf.

FnB news.com. [(accessed on 17 January 2019)]; Available online: http://www.fnbnews.com/Top-News/Unibic-presents-Chyawanprash-Cookies-to-focus-on-health-and-wellness-category.

India Mart. [(accessed on 15 January 2019)]; Available online: http://www.indiamart.com/baidyanath/immunomodulator.html.

The Hindu Sugar-Free Biscuits, Chyawanprash Come under Health Scanner. [(accessed on 15 January 2019)]; Available online: http://www.thehindubusinessline.com/todays-paper/sugarfree-biscuits-chyawanprash-come-under-health-scanner/article1633864.ece.

Sharma Y., Sharma M., Singh R., Katiyar C. Identification of mango and orange flavours in flavoured Chyawanprash by Gas Chromatography-Headspace. Int. J. Pharm. Life Sci. 2012;3:1953–1957.

Narayana D.B., Durg S., Manohar P.R., Mahapatra A., Aramya A.R. Chyawanprash: A review of therapeutic benefits as in authoritative texts and documented clinical literature. J. Ethnopharmacol. 2017;197:52–60. doi: 10.1016/j.jep.2016.07.078. PubMed DOI

Studies of Phytochemicals, Antioxidant, and Antibacterial Activities of Pinus gerardiana and Pinus roxburghii Seed Extracts

Influence of Family Environment and Tobacco Addiction: A Short Report from a Post-Graduate Teaching Hospital, India