The role of interleukin 22 in multiple sclerosis and its association with c-Maf and AHR
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Review
PubMed
31162488
DOI
10.5507/bp.2019.024
Knihovny.cz E-resources
- Keywords
- AHR, EAE, IL-22, c-Maf, multiple sclerosis, transcription factors,
- MeSH
- Adaptor Proteins, Signal Transducing physiology MeSH
- Interleukin-22 MeSH
- Interleukins physiology MeSH
- Humans MeSH
- Receptors, Aryl Hydrocarbon physiology MeSH
- Multiple Sclerosis etiology MeSH
- Basic Helix-Loop-Helix Transcription Factors physiology MeSH
- Transcription Factors physiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Adaptor Proteins, Signal Transducing MeSH
- AHR protein, human MeSH Browser
- CMIP protein, human MeSH Browser
- Interleukins MeSH
- Receptors, Aryl Hydrocarbon MeSH
- Basic Helix-Loop-Helix Transcription Factors MeSH
- Transcription Factors MeSH
The aim of this paper was to summarise knowledge of IL-22 involvement in multiple sclerosis (MS) and the possible link between IL-22 and two transcription factors - AHR and c-Maf. The conclusion is that despite numerous studies, the exact role of IL-22 in the pathogenesis of MS is still unknown. The expression and function of c-Maf in MS have not been studied. It seems that the functions of c-Maf and AHR are at least partly connected with IL-22, as both directly or indirectly influence the regulation of IL-22 expression. This possible connection has never been studied in MS.
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