Obesity is associated with additional left ventricular hypertrophy (LVH) in adults with hypertrophic cardiomyopathy (HCM). It is not known whether obesity can lead to further LVH in children with HCM. Echocardiographic LV dimensions were determined in 504 children with HCM. Measurements of interventricular septal thickness (IVST) and posterior wall thickness (PWT), and patients' weight and height were recorded. Obesity was defined as a body mass index (BMI) ≥ 99th percentile for age and sex. IVST data was available for 498 and PWT data for 484 patients. Patient age ranged from 2 to 20 years (mean ± SD, 12.5 ± 3.9) and 340 (68%) were males. Overall, patient BMI ranged from 7 to 50 (22.7 ± 6.1). Obesity (BMI 18-50, mean 29.1) was present in 140 children aged 2-19.6 (11.3 ± 4.1). The overall mean IVST was 20.5 ± 9.6 mm and the overall mean PWT was 11.0 ± 8.4 mm. The mean IVST in the obese patients was 21.6 ± 10.0 mm and mean PWT was 13.3 ± 14.7 mm. The mean IVST in the non-obese patients was 20.1 ± 9.5 mm and mean PWT was 10.4 ± 4.3 mm. Obesity was not significantly associated with IVST (p = 0.12), but was associated with increased PWT (0.0011). Obesity is associated with increased PWT but not IVST in children with HCM. Whether obesity and its impact on LVH influences clinical outcomes in children with HCM needs to be studied.

Advocate Hospital Chicago Chicago IL USA

Carolinas Health System Charlotte NC USA

Children's Hospital of Michigan Detroit MI USA

Children's Hospital of Omaha Omaha NE USA

Children's Hospital of Philadelphia Philadelphia PA USA

Children's Hospital of San Antonio San Antonio TX USA

CHLA Los Angeles CA USA

Cleveland Clinic Cleveland OH USA

Columbia University New York NY USA

Division of Cardiology Department of Pediatrics Oregon Health and Science University 707 SW Gaines Street Mailcode CDRC P Portland OR 97239 USA

German Heart Center Munich Munich Germany

Hospital for Sick Kids Toronto ON Canada

Mercy Children's Hospital Kansas City MO USA

Montefiore Hospital New York NY USA

Motol University Prague Czech Republic

Nationwide Children's Hospital Columbus OH USA

Northshore Hofstra University Hempstead NY USA

Phoenix Children's Hospital Phoenix AZ USA

Royal Children's Glasgow Glasgow UK

Royal Children's Melbourne Parkville VIC Australia

Sibley Heart Center Atlanta GA USA

St Louis University St Louis MO USA

UC Irvine Irvine CA USA

UCLA Los Angeles CA USA

UCSF San Francisco CA USA

University of Alberta Edmonton AB Canada

University of British Columbia Vancouver BC Canada

University of Cologne Cologne Germany

University of Colorado Boulder CO USA

University of Iowa Iowa City IA USA

University of Michigan Ann Arbor MI USA

University of Montreal Montreal QC Canada

University of Texas Southwestern Dallas TX USA

University of Utah Salt Lake City UT USA

University of Virginia Charlottesville VA USA

Vanderbilt University Nashville TN USA

Zobrazit více v PubMed

Expert Opin Investig Drugs. 2003 Nov;12(11):1757-9 PubMed

Pediatr Res. 2008 Aug;64(2):205-9 PubMed

Am J Cardiol. 2008 Jun 1;101(11):1621-5 PubMed

Am J Prev Med. 2009 Jul;37(1 Suppl):S97-104 PubMed

JACC Cardiovasc Imaging. 2010 Mar;3(3):266-74 PubMed

Obesity (Silver Spring). 2011 Jan;19(1):128-33 PubMed

J Pediatr. 2011 May;158(5):709-714.e1 PubMed

N Engl J Med. 1990 May 31;322(22):1561-6 PubMed

Circulation. 2011 Dec 13;124(24):2761-96 PubMed

J Am Coll Cardiol. 2013 Jul 30;62(5):449-57 PubMed

J Am Coll Cardiol. 2013 Jul 30;62(5):458-9 PubMed

Pediatr Cardiol. 2014 Feb;35(2):353-60 PubMed

Pediatr Nephrol. 2015 Apr;30(4):645-52 PubMed

J Am Coll Cardiol. 2015 Jun 2;65(21):2302-10 PubMed

J Pediatr. 1998 Jun;132(6):1023-7 PubMed