External validation of a postoperative nomogram for the prediction of disease-specific survival in patients with papillary renal cell carcinoma using a large multicenter database
Language English Country Japan Media print-electronic
Document type Journal Article, Validation Study
PubMed
31471787
DOI
10.1007/s10147-019-01530-x
PII: 10.1007/s10147-019-01530-x
Knihovny.cz E-resources
- Keywords
- Nomogram, Papillary, Prognosis, Renal cell carcinoma,
- MeSH
- Databases, Factual MeSH
- Carcinoma, Renal Cell mortality pathology surgery MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- Lymphatic Metastasis MeSH
- Multicenter Studies as Topic MeSH
- Kidney Neoplasms mortality pathology surgery MeSH
- Nomograms * MeSH
- Postoperative Period MeSH
- Prognosis MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Validation Study MeSH
PURPOSE: Based on data retrieved from a comprehensive multicenter database, we externally validated a published postoperative nomogram for the prediction of disease-specific survival (DSS) in patients with papillary renal cell carcinoma (papRCC). METHODS: A multicenter database containing data of 2325 patients with surgically treated papRCC was used as validation cohort. After exclusion of patients with missing data and patients included in the development cohort, 1372 patients were included in the final analysis. DSS-probabilities according to the nomogram were calculated and compared to actual DSS-probabilities. Subsequently, calibration plots and decision curve analyses were applied. RESULTS: The median follow-up was 38 months (IQR 11.8-80.7). Median DSS was not reached. The c-index of the nomogram was 0.71 (95% CI 0.60-0.83). A sensitivity analysis including only patients operated after 1998 delivered a c-index of 0.84 (95% CI 0.77-0.92). Calibration plots showed slight underestimation of nomogram-predicted DSS in probability ranges below 90%: median nomogram-predicted 5-year DSS in the range below 90% was 55% (IQR 20-80), but the median actual 5-year DSS in the same group was 58% (95% CI 52-65). Decision-curve analysis showed a positive net-benefit for probability ranges between a DSS probability of 5% and 85%. CONCLUSIONS: The nomogram performance was satisfactory for almost all DSS probabilities; hence it can be recommended for application in clinical routine and for counseling of patients with papRCC.
Department of Urology ASL Abruzzo2 Chieti Italy
Department of Urology ASL Abruzzo2 S Pio da Pietrelcina Hospital Vasto Italy
Department of Urology Elblandklinikum Riesa Weinbergstrasse 8 01589 Riesa Germany
Department of Urology Faculty of Medicine Charles University Pilsen Czech Republic
Department of Urology Hospital Bad Saarow Bad Saarow Germany
Department of Urology Instituto Nacional de Cancerologia INCan Mexico City Mexico
Department of Urology Klinikum St Elisabeth Straubing Germany
Department of Urology LMU Munich Grosshadern Munich Germany
Department of Urology Medical University of Graz Graz Austria
Department of Urology San Raffaele Scientific Institute Milan Italy
Department of Urology University Hospital Greifswald Greifswald Germany
Department of Urology University Hospital Mainz Mainz Germany
Department of Urology University Hospital Mannheim Mannheim Germany
Department of Urology University Hospital Muenster Muenster Germany
Division of Experimental Oncology Unit of Urology URI IRCCS San Raffaele Hospital Milan Italy
See more in PubMed
BMC Med Inform Decis Mak. 2008 Nov 26;8:53 PubMed
World J Urol. 2018 Dec;36(12):1953-1959 PubMed
J Urol. 2010 Jul;184(1):53-8 PubMed
Am J Surg Pathol. 1982 Oct;6(7):655-63 PubMed
Eur J Cancer. 2012 Oct;48(15):2347-52 PubMed
World J Urol. 2018 Dec;36(12):1943-1952 PubMed
World J Urol. 2018 Aug;36(8):1335-1336 PubMed
J Clin Oncol. 2005 Apr 20;23(12):2763-71 PubMed
World J Urol. 2018 Dec;36(12):1913-1926 PubMed
J Pathol. 1997 Oct;183(2):131-3 PubMed
Urology. 2017 Nov;109:107-114 PubMed
