INVESTIGATION OF THE RADIOPROTECTIVE EFFECT OF ORTHOVANADATE IN MICE AFTER TOTAL BODY IRRADIATION
Language English Country Great Britain, England Media print
Document type Journal Article
PubMed
31711201
DOI
10.1093/rpd/ncz192
PII: 5620710
Knihovny.cz E-resources
- MeSH
- B-Lymphocytes drug effects MeSH
- Killer Cells, Natural drug effects MeSH
- Whole-Body Irradiation * MeSH
- Cyclin-Dependent Kinase Inhibitor p21 metabolism MeSH
- Radiation, Ionizing MeSH
- Bone Marrow drug effects radiation effects MeSH
- Lymphocytes drug effects radiation effects MeSH
- Macrophages metabolism MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Tumor Suppressor Protein p53 metabolism MeSH
- Flow Cytometry MeSH
- Radiation-Protective Agents pharmacology MeSH
- T-Lymphocytes drug effects MeSH
- Vanadates pharmacology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cdkn1a protein, mouse MeSH Browser
- Cyclin-Dependent Kinase Inhibitor p21 MeSH
- Tumor Suppressor Protein p53 MeSH
- Radiation-Protective Agents MeSH
- Trp53 protein, mouse MeSH Browser
- Vanadates MeSH
The increasing risk of acute large-scale exposure of ionising irradiation on the population underlines the necessity of developing effective radioprotective and mitigating agents. The aim of this work was to investigate the effect of sodium orthovanadate pre-treatment on mice exposed to high doses of gamma rays (from 5 to 13 Gy). The determination of median lethal dose within 30 days confirmed that orthovanadate applied to total-body-irradiated mice intra-peritoneally has a radioprotective but not a mitigating effect. With orthovanadate pre-treatment, the composition of cellularity in the bone marrow improved substantially and the main lymphocyte populations restored during the first month after irradiation. These findings contribute to 'gap-filling' in radioprotective effects and demonstrate the importance of haematological parameters in radiation-response prediction.
Biomedical Research Center University Hospital 500 05 Hradec Kralove Czech Republic
Department of Radiobiology University of Defence 500 01 Hradec Kralove Czech Republic
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