SNPs within CHRNA5-A3-B4 and CYP2A6/B6, nicotine metabolite concentrations and nicotine dependence treatment success in smokers
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
31796940
DOI
10.5507/bp.2019.058
Knihovny.cz E-zdroje
- Klíčová slova
- CYP2A6/B6, EGLN2, cotinine, hydroxycotinine, intensive treatment, nicotine metabolism, nicotine-acetylcholine receptors, smoking, tobacco dependence,
- MeSH
- cytochrom P450 CYP2A6 genetika MeSH
- cytochrom P450 CYP2B6 genetika MeSH
- dospělí MeSH
- jednonukleotidový polymorfismus * MeSH
- lidé středního věku MeSH
- lidé MeSH
- nikotin krev metabolismus MeSH
- nikotinové receptory genetika MeSH
- poruchy vyvolané užíváním tabáku krev genetika metabolismus terapie MeSH
- proteiny nervové tkáně genetika MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- CHRNA5 protein, human MeSH Prohlížeč
- CYP2A6 protein, human MeSH Prohlížeč
- CYP2B6 protein, human MeSH Prohlížeč
- cytochrom P450 CYP2A6 MeSH
- cytochrom P450 CYP2B6 MeSH
- nikotin MeSH
- nikotinové receptory MeSH
- proteiny nervové tkáně MeSH
AIM: Plasma values of nicotine and its metabolites are highly variable, and this variability has a strong genetic influence. In our study, we analysed the impact of common polymorphisms associated with smoking on the plasma values of nicotine, nicotine metabolites and their ratios and investigated the potential effect of these polymorphisms and nicotine metabolite ratios on the successful treatment of tobacco dependence. METHODS: Five variants (rs16969968, rs6474412, rs578776, rs4105144 and rs3733829) were genotyped in a group of highly dependent adult smokers (n=103). All smokers underwent intensive treatment for tobacco dependence; 33 smokers were still abstinent at the 12-month follow-up. RESULTS: The rs4105144 (CYP2A6, P<0.005) and rs3733829 (EGLN2, P<0.05) variants were significantly associated with plasma concentrations of 3OH-cotinine and with 3OH-cotinine: cotinine ratios. Similarly, the unweighted gene score was a significant (P<0.05) predictor of both cotinine:nicotine and 3OH-cotinine:cotinine ratios. No associations between the analysed polymorphisms or nicotine metabolite ratios and nicotine abstinence rate were observed. CONCLUSION: Although CYP2A6 and EGLN2 polymorphisms were associated with nicotine metabolism ratios, neither these polymorphisms nor the ratios were associated with abstinence rates.
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