Double stimuli-responsive cellulose nanocrystals reinforced electrospun PHBV composites membrane for intelligent drug release
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
32229207
DOI
10.1016/j.ijbiomac.2020.03.216
PII: S0141-8130(20)32803-8
Knihovny.cz E-zdroje
- Klíčová slova
- Cellulose nanocrystals, Drug release, Electrospinning, Nanofiber membrane,
- MeSH
- celulosa chemie MeSH
- hydrofobní a hydrofilní interakce MeSH
- krystalizace MeSH
- membrány chemie MeSH
- methakryláty chemie MeSH
- nanočástice chemie MeSH
- nanokompozity chemie MeSH
- nylony chemie MeSH
- teoretické modely MeSH
- teplota MeSH
- uvolňování léčiv * MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- celulosa MeSH
- methakryláty MeSH
- nylony MeSH
- poly(2-(dimethylamino)ethyl methacrylate) MeSH Prohlížeč
Double stimuli-responsive functionalized cellulose nanocrystal-poly[2-(dimethylamino)ethyl methacrylate] (CNC-g-PDMAEMA) reinforced poly(3-hydroxybutyrate-co-3-hydroxy valerate) (PHBV) electrospun composite membranes were explored as drug delivery vehicles using tetracycline hydrochloride (TH) as a model drug. It was found that rigid CNC-g-PDMAEMA nanoparticles enhanced thermal, crystallization and hydrophilic properties of PHBV. Moreover, great improvements in fiber diameter uniformity, crystallization ability and maximum decomposition temperature (Tmax) could be achieved at 6 wt% CNC-g-PDMAEMA. Furthermore, by introducing stimuli-responsive CNC-g-PDMAEMA nanofillers, intelligent and long-term sustained release behavior of composite membranes could be achieved. The releasing mechanism of composite membranes based on zero order, first order, Higuchi and Korsmeyere-Peppas mathematical models was clearly demonstrated, giving effective technical guidance for practical drug delivery systems.
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