Suspect and non-targeted screening of chemicals of emerging concern for human biomonitoring, environmental health studies and support to risk assessment: From promises to challenges and harmonisation issues
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
32361063
DOI
10.1016/j.envint.2020.105545
PII: S0160-4120(19)33831-0
Knihovny.cz E-resources
- Keywords
- Biomonitoring, Chemical of emerging concern, High resolution mass spectrometry, Metabolites, Non-targeted screening, Suspect screening,
- MeSH
- Biological Monitoring * MeSH
- Chromatography, Liquid MeSH
- Environmental Health MeSH
- Environmental Pollutants * analysis toxicity MeSH
- Humans MeSH
- Environmental Monitoring MeSH
- Environmental Exposure analysis MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Environmental Pollutants * MeSH
Large-scale suspect and non-targeted screening approaches based on high-resolution mass spectrometry (HRMS) are today available for chemical profiling and holistic characterisation of biological samples. These advanced techniques allow the simultaneous detection of a large number of chemical features, including markers of human chemical exposure. Such markers are of interest for biomonitoring, environmental health studies and support to risk assessment. Furthermore, these screening approaches have the promising capability to detect chemicals of emerging concern (CECs), document the extent of human chemical exposure, generate new research hypotheses and provide early warning support to policy. Whilst of growing importance in the environment and food safety areas, respectively, CECs remain poorly addressed in the field of human biomonitoring. This shortfall is due to several scientific and methodological reasons, including a global lack of harmonisation. In this context, the main aim of this paper is to present an overview of the basic principles, promises and challenges of suspect and non-targeted screening approaches applied to human samples as this specific field introduce major specificities compared to other fields. Focused on liquid chromatography coupled to HRMS-based data acquisition methods, this overview addresses all steps of these new analytical workflows. Beyond this general picture, the main activities carried out on this topic within the particular framework of the European Human Biomonitoring initiative (project HBM4EU, 2017-2021) are described, with an emphasis on harmonisation measures.
HERACLES Research Center on the Exposome and Health Aristotle University of Thessaloniki Greece
Institute for Risk Assessment Sciences Utrecht University Utrecht the Netherlands
Institute of Legal Medicine and Core Facility Metabolomics Medical University of Innsbruck Austria
Oniris INRAE LABERCA Nantes France
RECETOX Centre Masaryk University Brno Czech Republic
Toxicological Center University of Antwerp Belgium
UFZ Helmholtz Centre for Environmental Research Leipzig Germany
Vrije Universiteit Department Environment and Health Amsterdam the Netherlands
References provided by Crossref.org
A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe
The Exposome and Toxicology: A Win-Win Collaboration
