Comparative study of the substantia nigra echogenicity and 123I-Ioflupane SPECT in patients with synucleinopathies with and without REM sleep behavior disorder
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Odkazy
PubMed
32403038
DOI
10.1016/j.sleep.2020.02.012
PII: S1389-9457(20)30085-X
Knihovny.cz E-zdroje
- Klíčová slova
- Dopamine transporter imaging, Idiopathic rapid-eye-movement sleep behavior disorder, Neuroimaging, Parkinson's disease, Substantia nigra hyperechogenicity, Transcranial sonography,
- MeSH
- jednofotonová emisní výpočetní tomografie MeSH
- lidé MeSH
- nortropany MeSH
- porucha chování v REM spánku * diagnostické zobrazování patofyziologie MeSH
- radioizotopy jodu MeSH
- substantia nigra * diagnostické zobrazování patofyziologie MeSH
- synukleinopatie * diagnostické zobrazování patofyziologie MeSH
- ultrasonografie dopplerovská transkraniální MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- Iodine-123 MeSH Prohlížeč
- ioflupane MeSH Prohlížeč
- nortropany MeSH
- radioizotopy jodu MeSH
OBJECTIVES: Hyperechogenicity of the substantia nigra (SN) and abnormal dopamine transporter-single-photon emission computed tomography (DAT-SPECT) are biomarkers commonly used in the assessment of prodromal synucleinopathy. Our goals were as follows: (1) to compare echogenicity of SN in idiopathic rapid eye movement (REM) behavior disorder (iRBD), Parkinson's disease (PD) without RBD (PD-noRBD), PD with RBD (PD + RBD), and control subjects; and (2) to examine association between SN degeneration assessed by DAT-SPECT and SN echogenicity. PATIENTS/METHODS: A total of 61 subjects with confirmed iRBD were examined using Movement Disorders Society-unified PD rating scale (MDS-UPDRS), TCS (transcranial sonography) and DAT-SPECT. The results were compared with 44 patients with PD (25% PD + RBD) and with 120 age-matched healthy subjects. RESULTS AND CONCLUSION: The abnormal SN area was found in 75.5% PD, 23% iRBD and 7.3% controls. Median SN echogenicity area in PD (0.27 ± 0.22 cm2) was higher compared to iRBD (0.07 ± 0.07 cm2; p < 0.0001) and controls (0.05 ± 0.03 cm2; p < 0.0001). SN echogenicity in PD + RBD was not significantly different from PD-noRBD (0.30 vs. 0.22, p = 0.15). Abnormal DAT-SPECT was found in 16 iRBD (25.4%) and 44 PD subjects (100%). No correlation between the larger SN area and corresponding putaminal binding index was found in iRBD (r = -0.13, p = 0.29), nor in PD (r = -0.19, p = 0.22). The results of our study showed that: (1) SN echogenicity area in iRBD was higher compared to controls, but the hyperechogenicity was present only in a minority of iRBD patients; (2) SN echogenicity and DAT-SPECT binding index did not correlate in either group; and (3) SN echogenicity does not differ between PD with/without RBD.
Whole brain pattern of iron accumulation in REM sleep behavior disorder