This work explores the design and implementation of an algorithm for the classification of magnetic resonance imaging data for computer-aided diagnosis of schizophrenia. Features for classification were first extracted using two morphometric methods: voxel-based morphometry (VBM) and deformation-based morphometry (DBM). These features were then transformed into a wavelet domain using the discrete wavelet transform with various numbers of decomposition levels. The number of features was then reduced by thresholding and subsequent selection by: Fisher's Discrimination Ratio (FDR), Bhattacharyya Distance, and Variances (Var.). A Support Vector Machine with a linear kernel was used for classification. The evaluation strategy was based on leave-one-out cross-validation.

Brno University of Technology Technická 3058 10 61600 Brno Czech Republic

Institute of Biostatistics and Analyses Ltd Czech Republic

Masaryk University Faculty of Medicine Kamenice 5 62500 Brno Czech Republic

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