Fibroblasts: The grey eminence of mammary gland development
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
33158729
DOI
10.1016/j.semcdb.2020.10.012
PII: S1084-9521(20)30169-5
Knihovny.cz E-resources
- Keywords
- Breast, Epithelial-stromal interactions, Fibroblast, Heterogeneity, Mammary gland, Microenvironment,
- MeSH
- Fibroblasts metabolism MeSH
- Humans MeSH
- Mammary Glands, Human growth & development MeSH
- Mammary Glands, Animal growth & development MeSH
- Disease Models, Animal MeSH
- Mice MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The essential role of mammary gland stroma in the regulation of mammary epithelial development, function, and cancer has long been recognized. Only recently, though, the functions of individual stromal cell populations have begun to become more clarified. Mammary fibroblasts have emerged as master regulators and modulators of epithelial cell behavior through paracrine signaling, extracellular matrix production and remodeling, and through regulation of other stromal cell types. In this review article, we summarize the crucial studies that helped to untangle the roles of fibroblasts in mammary gland development. Furthermore, we discuss the origin, heterogeneity, and plasticity of mammary fibroblasts during mammary development and cancer progression.
References provided by Crossref.org
Fibroblast-Epithelium Co-culture Methods Using Epithelial Organoids and Cell Line-Derived Spheroids
Fibroblast-induced mammary epithelial branching depends on fibroblast contractility
