Corpus Callosum Growth and Neurodevelopmental Outcome Are Negatively Influenced by Systemic Infection in Very Low-Birth-Weight Infants
Language English Country United States Media print-electronic
Document type Journal Article, Observational Study, Research Support, Non-U.S. Gov't
- Keywords
- Preterm newborn, corpus callosum, systemic infection,
- MeSH
- Corpus Callosum diagnostic imaging growth & development MeSH
- Causality MeSH
- Cohort Studies MeSH
- Infant MeSH
- Humans MeSH
- Follow-Up Studies MeSH
- Neurodevelopmental Disorders epidemiology MeSH
- Infant, Premature MeSH
- Infant, Very Low Birth Weight MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Prospective Studies MeSH
- Sepsis epidemiology MeSH
- Ultrasonography methods MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Male MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
Systemic infection may negatively modulate the development of cerebral white matter and long-term outcome of neonates. We analyzed the growth of corpus callosum (using cranial ultrasonography) and neurodevelopment (Bayley Scales of Infant Development, Third Edition) in 101 very low-birth-weight newborns. We observed significantly reduced corpus callosum length at 3 months of corrected age (44.5 mm vs 47.7 mm, P = .004) and diminished corpus callosum growth (0.07 mm/d vs 0.08 mm/d, P = .028) in infants who experienced systemic infection. The subgroup exhibited inferior neurodevelopmental outcomes with predominant motor impairment. The results suggest that length and growth of corpus callosum might be affected by systemic inflammatory response in preterm newborns. The changes in corpus callosum can contribute to adverse neurodevelopment at 2 years of corrected age. Serial ultrasonographic measurements of the corpus callosum may be suitable to identify preterm infants with increased risk of neurodevelopmental impairment.
Charles University 3rd Faculty of Medicine Prague Czech Republic
Institute for the Care of Mother and Child Neonatology Prague Czech Republic
References provided by Crossref.org
