The sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement for this challenging group of substances. However, the success of this approach for a particular API depends on an array of factors including the properties of the porous carrier, the loading method, or the attempted mass fraction of the API. At present, there is no established methodology for the rational selection of these parameters. In the present work, we report a systematic comparison of four well-characterised silica carriers and seven APIs loaded by the same solvent evaporation method. In each case, we find the maximum amorphization capacity by x-ray powder diffraction analysis and measure the in vitro drug release kinetics. For a selected case, we also demonstrate the potential for bioavailability enhancement by a permeation essay.

Department of Chemical Engineering University of Chemistry and Technology Prague Technická 5 166 28 Prague 6 Czech Republic

Department of Chemical Engineering University of Chemistry and Technology Prague Technická 5 166 28 Prague 6 Czech Republic; Zentiva k s U Kabelovny 130 102 00 Praha 10 Czech Republic

Department of Chemical Engineering University of Chemistry and Technology Prague Technická 5 166 28 Prague 6 Czech Republic; Zentiva k s U Kabelovny 130 102 00 Praha 10 Czech Republic; Department of Pharmacy UiT The Arctic University of Norway Norway

Department of Pharmacy UiT The Arctic University of Norway Norway

Zentiva k s U Kabelovny 130 102 00 Praha 10 Czech Republic

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