Corpus callosum hypersignals and focal atrophy: Neuroimaging findings in globular glial tauopathy type I
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
34469612
PubMed Central
PMC9290577
DOI
10.1111/ene.15090
Knihovny.cz E-resources
- Keywords
- corpus callosum, dementia, globular glial tauopathy, magnetic resonance, tauopathy,
- MeSH
- Atrophy pathology MeSH
- Corpus Callosum * pathology MeSH
- Humans MeSH
- Neuroimaging MeSH
- Retrospective Studies MeSH
- Tauopathies * complications diagnostic imaging MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND AND PURPOSE: Globular glial tauopathies (GGTs) have heterogeneous presentations; little evidence regarding typical clinical and magnetic resonance imaging (MRI) presentations are available. METHODS: We retrospectively assessed MRIs from three postmortem-confirmed GGT cases, in two patients with atypical progressive aphasia and one with corticobasal syndrome. RESULTS: We suggest that four principal concomitant MRI findings characterize GGT type I: a sagittal callosal hyperintense band, marked focal callosal atrophy suggesting white matter degeneration originating in cortical areas responsible for symptoms (anterior atrophy in predominantly language manifestations and posterior atrophy in predominantly apraxia), periventricular white matter lesions, and mild-to-moderate brain stem atrophy. CONCLUSIONS: We observed four concomitant MRI abnormalities in patients with atypical dementia, parkinsonism, and late incomplete supranuclear gaze palsy. Two patients had atypical progressive aphasia and one had corticobasal syndrome.
3rd Faculty of Medicine Charles University Prague Czech Republic
Department of Communication Disorders Comenius University Bratislava Slovakia
Department of Neurology Thomayer University Hospital Prague Czech Republic
Department of Pathology and Molecular Medicine Thomayer University Hospital Prague Czech Republic
Department of Radiology Na Homolce Hospital Prague Czech Republic
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