Apelin-13 facilitates lordosis behavior following infusions to the ventromedial hypothalamus or preoptic area in ovariectomized, estrogen-primed rats
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
35150776
DOI
10.1016/j.neulet.2022.136518
PII: S0304-3940(22)00075-1
Knihovny.cz E-resources
- Keywords
- Apelin-13, Lordosis, Preoptic area, Ventromedial hypothalamus,
- MeSH
- Preoptic Area * drug effects pathology MeSH
- Estradiol pharmacology MeSH
- Estrogens pharmacology MeSH
- Hypothalamus drug effects pathology MeSH
- Rats MeSH
- Lordosis * chemically induced MeSH
- Intercellular Signaling Peptides and Proteins * pharmacology MeSH
- Ventromedial Hypothalamic Nucleus drug effects pathology MeSH
- Progesterone pharmacology MeSH
- Sexual Behavior, Animal drug effects MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- apelin-13 peptide MeSH Browser
- Estradiol MeSH
- Estrogens MeSH
- Intercellular Signaling Peptides and Proteins * MeSH
- Progesterone MeSH
In normal hormonal conditions, increased neuronal activity in the ventromedial hypothalamus (VMH) induces lordosis whereas activation of the preoptic area (POA) exerts an opposite effect. In the present work, we explored the effect of bilateral infusion of different doses of the apelin-13 (0.37, 0.75, 1.5, and 15 μg) in both brain areas on the expression of lordosis behavior. Lordosis quotient and lordosis reflex score were performed at 30, 120, and 240 min. Weak lordosis was observed following the 0.37 μg dose of apelin-13 at 30 min in the VMH of EB-primed rats; however, the rest of the doses induced significant lordosis relative to the control group. At 120 min, all doses induced lordosis behavior, while at 240 min, the highest dose of 15 μg did not induce significant differences. Interestingly, only the 0.75 μg infusion of apelin in the POA induced significant lordosis at 120 and 240 min. These results indicate that apelin-13 acts preferably in HVM and slightly in POA to initiate lordosis behavior in estrogen-primed rats.
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