Effect of Bisphenol S on testicular tissue after low-dose lactation exposure
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
PubMed
36096261
DOI
10.1016/j.envpol.2022.120114
PII: S0269-7491(22)01328-8
Knihovny.cz E-resources
- Keywords
- Bisphenol S, Blood-testis barrier, Idiopathic infertility, Lactation exposure, Oxidative stress, Testicular tissue,
- MeSH
- Benzhydryl Compounds toxicity MeSH
- Endocrine Disruptors * toxicity MeSH
- Lactation * MeSH
- Mice MeSH
- Sulfones toxicity MeSH
- Testis MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Benzhydryl Compounds MeSH
- bisphenol S MeSH Browser
- Endocrine Disruptors * MeSH
- Sulfones MeSH
Exposure to endocrine disruptors such as bisphenols, can lead to and be the explanation for idiopathic infertility. In our study, we assessed the effect of exposure to bisphenol S (BPS) via breast milk on the testicular tissue health of adult male mice. Lactating dams were exposed to BPS through drinking water (0.216 ng g bw/day and 21.6 ng g bw/day) from post-natal day 0-15. Although there was no significant difference in testicular histopathology between the control and experimental groups, we observed an increase in the number of tight and gap junctions in the blood-testis barrier (BTB) of adult mice after lactation BPS exposure. Moreover, there was an increase in oxidative stress markers in adult testicular tissue of mice exposed via breast milk. Our lactation model indicates that breast milk is a route of exposure to an endocrine disruptor that can be responsible for idiopathic male infertility through the damage of the BTB and weakening of oxidative stress resistance in adulthood.
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