Ventricular fibrillation and arrhythmia associated with cardiac fibromas involving both ventricles in a 1.5-year-old girl
Status PubMed-not-MEDLINE Language English Country Germany Media print-electronic
Document type Journal Article
PubMed
36778761
PubMed Central
PMC9904519
DOI
10.1007/s00194-023-00615-2
PII: 615
Knihovny.cz E-resources
- Keywords
- Cardiac fibroma, Cardiac tumors, Gorlin-Goltz syndrome, Osseous metaplasia of the central fibrous body, Ventricular arrhythmia, Ventricular tachycardia,
- Publication type
- Journal Article MeSH
This article reports the autopsy findings of a 1.5-year-old girl with no history of previous hospital admission who suddenly collapsed at home. After 45 minutes of resuscitation efforts, the cardiac activity was restored. During hospitalization, she had ventricular arrhythmia and extremely elevated cardiac troponin levels. Internal examination and immunohistochemistry revealed cardiac fibromas of the right and left ventricles and extensive hypoxic myocardial damage. The right ventricular fibroma demonstrated interdigitating and entrapped myocardium visible at the edges and within the central portion of the tumor. The left ventricular fibroma originated in the subepicardial region and propagated towards the endocardium.
In diesem Artikel wird über die Autopsiebefunde eines 1,5-jährigen Mädchens ohne vorherige Krankenhauseinweisung berichtet, das plötzlich zu Hause zusammenbrach. Nach 45-minütigen Reanimationsbemühungen war die Herzaktivität wiederhergestellt. Während des Krankenhausaufenthalts litt sie unter ventrikulären Arrhythmien und extrem erhöhten kardialen Troponinspiegeln. Klinische Diagnostik und Immunhistochemie ergaben ein Herzfibrom des rechten und linken Ventrikels und einen ausgedehnten hypoxischen Myokardschaden. Das Fibrom des rechten Ventrikels zeigte ineinandergreifendes und eingeschlossenes Myokard, das an den Rändern und innerhalb des zentralen Teils des Tumors sichtbar war. Das linksventrikuläre Fibrom entstand in der subepikardialen Region und breitete sich zum Endokard aus.
Department of Forensic Medicine Faculty of Medicine Pavol Jozef Šafárik University Košice Slovakia
Department of Heart Surgery East Slovak Institute of Cardiovascular Disease Košice Slovakia
Department of Pathology Louis Pasteur University Hospital Košice Slovakia
Laboratory of Molecular Biology Agel Nový Jičín a s Nový Jičín Czech Republic
See more in PubMed
Burke AP, Rosado-de-Christenson M, Templeton PA, Virmani R. Cardiac fibroma: clinicopathologic correlates and surgical treatment. J Thorac Cardiovasc Surg. 1994;108:862–870. doi: 10.1016/S0022-5223(94)70184-9. PubMed DOI
Williams DB, Danielson GK, McGoon DC, Feldt RH, Edwards WD. Cardiac fibroma: long-term survival after excision. J Thorac Cardiovasc Surg. 1982;84:230–236. doi: 10.1016/S0022-5223(19)39038-5. PubMed DOI
Engle MA, Ebert PA, Redo SF. Recurrent ventricular tachycardia due to resectable cardiac tumor. Circulation. 1974;50:1052–1057. doi: 10.1161/01.CIR.50.5.1052. PubMed DOI
Carreon CK, Sanders SP, Perez-Atayde AR, Del Nido PD, Walsh EP, Geva T, Alexander ME. Interdigitating myocardial tongues in pediatric cardiac fibromas: a plausible substrate for ventricular tachycardia and cardiac arrest. JACC Clin Electrophysiol. 2019;5:563–575. doi: 10.1016/j.jacep.2019.01.022. PubMed DOI
Mecchia D, Lavezzi AM, Matturri L. Primary cardiac fibroma and cardiac conduction system alterations in a case of the sudden death of a 4-month-old infant. Open Cardiovasc Med J. 2013;7:47–49. doi: 10.2174/1874192401307010047. PubMed DOI PMC
Uzun O, Wilson DG, Vujanic GM, Parsons JM, De Giovanni JV. Cardiac tumors in children. Orphanet J Rare Dis. 2007;2:11. doi: 10.1186/1750-1172-2-11. PubMed DOI PMC
Luschka H. Ein Fibroid im Herzfleische. Virchows Arch. A. Pathol. Anat. Histol. 1855;8:343–347. doi: 10.1007/BF01935306. DOI
Buja LM, Butany J. Cardiovascular pathology. Cambridge: Academic Press, Elsevier; 2015.
Matějková A, Fabián O. Diferenciální diagnostika tumorózních lézí srdce. Cesk Patol. 2020;56:18–25. PubMed
Coffin CM. Congenital cardiac fibroma associated with Gorlin syndrome. Pediatr Pathol. 1992;12:255–262. doi: 10.3109/15513819209023303. PubMed DOI
Bartoš V, Kullová M, Adamicová K, Paučinová I. Gorlin-Goltz syndrome. Klin Onkol. 2019;32:124–128. doi: 10.14735/amko2019124. PubMed DOI
Miyake CY, Del Nido PJ, Alexander ME, Cecchin F, Berul CI, Triedman JK, Geva T, Walsh EP. Cardiac tumors and associated arrhythmias in pediatric patients, with observations on surgical therapy for ventricular tachycardia. J Am Coll Cardiol. 2011;58:1903–1909. doi: 10.1016/j.jacc.2011.08.005. PubMed DOI
Geha AS, Weidman WH, Soule EH, McGoon DC. Intramural ventricular cardiac fibroma. Successful removal in two cases and review of the literature. Circulation. 1967;36:427–440. doi: 10.1161/01.cir.36.3.427. PubMed DOI
Colmorn LB, Jensen T, Petersen BL, Helvind M, Jørgensen FS. Prenatal ultrasound diagnosis of a multiple atypical right atrial cardiac fibroma. Ultraschall Med. 2012;33:85–86. doi: 10.1055/s-0029-1245552. PubMed DOI
István K, Törő K, Kardos M, Imre C, György D, Agnes N. Sudden death due to infiltration of left bundle branches by interventricular septal cardiac fibroma. J Forensic Sci. 2012;57:1669–1674. doi: 10.1111/j.1556-4029.2012.02255.x. PubMed DOI
Coppoletta JM, Wolbach SB. Body length and organ weights of infants and children: a study of the body length and normal weights of the more important vital organs of the body between birth and twelve years of age. Am J Pathol. 1933;9:55–70. PubMed PMC
Hadravská Š, Dubová M, Miesbauerová M, Mukenšnabl P, Daum O, Mádle A, Smetana K. Hamartom ze zralých kardiomyocytů. Pitevní kazuistika. Cesk Patol. 2017;53:185–187. PubMed
Otsuka T, Asano K, Murota Y, Fukuda S, Hada Y, Fujii J. Successful removal of a cardiac fibroma in an elderly patient. J Cardiovasc Surg. 1990;31:55–57. PubMed
Yamaguchi M, Hosokawa Y, Ohashi H, Imai M, Oshima Y, Minamiji K. Cardiac fibroma: long-term fate after excision. J Thorac Cardiovasc Surg. 1992;103:140–145. doi: 10.1016/S0022-5223(19)35076-7. PubMed DOI
Parks FR, Jr, Adams F, Longmire WR., Jr Successful excision of a left ventricular hamartoma. Report of a case. Circulation. 1962;26:1316–1320. doi: 10.1161/01.CIR.26.6.1316. PubMed DOI
Jawa DS, Sircar K, Somani R, Grover N, Jaidka S, Singh S. Gorlin-Goltz syndrome. J Oral Maxillofac Pathol. 2009;13:89–92. doi: 10.4103/0973-029X.57677. PubMed DOI PMC
Lopes NN, Caran EM, Lee ML, Silva NS, Rocha AC, Macedo CR. Gorlin-Goltz syndrome and neoplasms: a case study. J Clin Pediatr Dent. 2010;35:203–206. doi: 10.17796/jcpd.35.2.x01248284w166485. PubMed DOI