• This record comes from PubMed

Six years of the Angels Initiative: Aims, achievements, and future directions to improve stroke care worldwide

. 2023 Oct ; 18 (8) : 898-907. [epub] 20230802

Language English Country United States Media print-electronic

Document type Journal Article, Review, Research Support, Non-U.S. Gov't

The rate of stroke-related death and disability is four times higher in low- and middle-income countries (LMICs) than in high-income countries (HICs), yet stroke units exist in only 18% of LMICs, compared with 91% of HICs. In order to ensure universal and equitable access to timely, guideline-recommended stroke care, multidisciplinary stroke-ready hospitals with coordinated teams of healthcare professionals and appropriate facilities are essential.Established in 2016, the Angels Initiative is an international, not-for-profit, public-private partnership. It is run in collaboration with the World Stroke Organization, European Stroke Organisation, and regional and national stroke societies in over 50 countries. The Angels Initiative aims to increase the global number of stroke-ready hospitals and to optimize the quality of existing stroke units. It does this through the work of dedicated consultants, who help to standardize care procedures and build coordinated, informed communities of stroke professionals. Angels consultants also establish quality monitoring frameworks using online audit platforms such as the Registry of Stroke Care Quality (RES-Q), which forms the basis of the Angels award system (gold/platinum/diamond) for all stroke-ready hospitals across the world.The Angels Initiative has supported over 1700 hospitals (>1000 in LMICs) that did not previously treat stroke patients to become "stroke ready." Since its inception in 2016, the Angels Initiative has impacted the health outcomes of an estimated 7.46 million stroke patients globally (including an estimated 4.68 million patients in LMICs). The Angels Initiative has increased the number of stroke-ready hospitals in many countries (e.g. in South Africa: 5 stroke-ready hospitals in 2015 vs 185 in 2021), reduced "door to treatment time" (e.g. in Egypt: 50% reduction vs baseline), and increased quality monitoring substantially.The focus of the work of the Angels Initiative has now expanded from the hyperacute phase of stroke treatment to the pre-hospital setting, as well as to the early post-acute setting. A continued and coordinated global effort is needed to achieve the target of the Angels Initiative of >10,000 stroke-ready hospitals by 2030, and >7500 of these in LMICs.

See more in PubMed

World Stroke Organization. Global survey reveals only 35% hospitals worldwide provide life-saving stroke treatment, https://www.world-stroke.org/news-and-blog/news/global-survey-reveals-only-35-hospitals-worldwide-provide-life-saving-stroke-treatment (2021, accessed 12 December 2022).

Saini V, Guada L, Yavagal DR. Global epidemiology of stroke and access to acute ischemic stroke interventions. Neurology 2021; 97: S6–S16. PubMed

Stroke Alliance for Europe (SAFE). The burden of stroke in Europe, https://strokeeurope.eu/executive-summary/ (2022, accessed 27 September 2022).

Owolabi MO, Thrift AG, Martins S, et al. The state of stroke services across the globe: report of World Stroke Organization-World Health Organization surveys. Int J Stroke 2021; 16: 889–901. PubMed PMC

Feigin VL, Brainin M, Norrving B, et al. World Stroke Organization (WSO): global stroke fact sheet 2022. Int J Stroke 2022; 17: 18–29. PubMed

Langhorne P, Ramachandra S; Stroke Unit Trialists’ Collaboration. Organised inpatient (stroke unit) care for stroke: network meta-analysis. Cochrane Database Syst Rev 2020; 4: CD000197. PubMed PMC

Boehringer Ingelheim. TOMORROW: research for a healthier future. Ingelheim am Rhein: Boehringer Ingelheim, 2022.

Boehringer Ingelheim. Saving stroke patients around the world, https://www.boehringer-ingelheim.com/sustainable-development/more-health/saving-stroke-patients-around-world (2022, accessed 5 December 2022).

Boehringer Ingelheim. Home page, https://www.angels-initiative.com/ (2022, accessed 4 July 2022).

Fladt J, Meier N, Thilemann S, et al. Reasons for prehospital delay in acute ischemic stroke. J Am Heart Assoc 2019; 8: e013101. PubMed PMC

Abraham SV, Krishnan SV, Thaha F, Balakrishnan JM, Thomas T, Palatty BU. Factors delaying management of acute stroke: an Indian scenario. Int J Crit Illn Inj Sci 2017; 7: 224–230. PubMed PMC

Herpich F, Rincon F. Management of acute ischemic stroke. Crit Care Med 2020; 48: 1654–1663. PubMed PMC

Broderick JP. Logistics in acute stroke management. Drugs 1997; 54: 109–116; discussion 116–117. PubMed

Skolarus LE, Sales AE, Zimmerman MA, et al. Stroke ready: a multi-level program that combines implementation science and community-based participatory research approaches to increase acute stroke treatment: protocol for a stepped wedge trial. Implement Sci 2019; 14: 24. PubMed PMC

Kidwell CS, Starkman S, Eckstein M, Weems K, Saver JL. Identifying stroke in the field. Prospective validation of the Los Angeles Prehospital Stroke Screen (LAPSS). Stroke 2000; 31: 71–76. PubMed

Binning MJ, Sanfillippo G, Rosen W, et al. The neurological emergency room and prehospital stroke alert: the whole is greater than the sum of its parts. Neurosurgery 2014; 74: 281–285; discussion 285. PubMed

Rønning OM, Guldvog B. Stroke units versus general medical wards, I: twelve- and eighteen-month survival: a randomized, controlled trial. Stroke 1998; 29: 58–62. PubMed

Rodgers H, Price C. Stroke unit care, inpatient rehabilitation and early supported discharge. Clin Med 2017; 17: 173–177. PubMed PMC

Dion JE. Management of ischemic stroke in the next decade: stroke centers of excellence. J Vasc Interv Radiol 2004; 15: S133–S141. PubMed

Alberts MJ, Wechsler LR, Jensen ME, et al. Formation and function of acute stroke-ready hospitals within a stroke system of care recommendations from the brain attack coalition. Stroke 2013; 44: 3382–3393. PubMed

Alberts MJ, Hademenos G, Latchaw RE, et al. Recommendations for the establishment of primary stroke centers. Brain Attack Coalition. JAMA 2000; 283: 3102–3109. PubMed

Mosley I, Morphet J, Innes K, Braitberg G. Triage assessments and the activation of rapid care protocols for acute stroke patients. Australas Emerg Nurs J 2013; 16: 4–9. PubMed

Yang SJ, Franco T, Wallace N, Williams B, Blackmore C. Effectiveness of an interdisciplinary, nurse driven in-hospital code stroke protocol on in-patient ischemic stroke recognition and management. J Stroke Cerebrovasc Dis 2019; 28: 104398. PubMed

Aguiar de, Sousa D, von Martial R, Abilleira S, et al. Access to and delivery of acute ischaemic stroke treatments: a survey of national scientific societies and stroke experts in 44 European countries. Eur Stroke J 2019; 4: 13–28. PubMed PMC

Olavarría VV, Hoffmeister L, Vidal C, Brunser AM, Hoppe A, Lavados PM. Temporal trends of intravenous thrombolysis utilization in acute ischemic stroke in a prospective cohort from 1998 to 2019: modeling based on Joinpoint regression. Front Neurol 2022; 13: 851498. PubMed PMC

Oliveira-Filho J, Samuels OB. Mechanical thrombectomy for acute ischemic stroke, https://www.uptodate.com/contents/mechanical-thrombectomy-for-acute-ischemic-stroke#H3605591778 (2022, accessed 4 July 2022).

Jadhav AP, Desai SM, Kenmuir CL, et al. Eligibility for endovascular trial enrollment in the 6- to 24-hour time window: analysis of a single comprehensive stroke center. Stroke 2018; 49: 1015–1017. PubMed

Trifan G, Biller J, Testai FD. Mechanical thrombectomy vs bridging therapy for anterior circulation large vessel occlusion stroke: systematic review and meta-analysis. Neurology 2022; 98: e1361–e1373. PubMed

Green TL, McNair ND, Hinkle JL, et al. Care of the patient with acute ischemic stroke (posthyperacute and prehospital discharge): update to 2009 comprehensive nursing care scientific statement: a scientific statement from the American Heart Association. Stroke 2021; 52: e179–e197. PubMed

Purvis T, Middleton S, Craig LE, et al. Inclusion of a care bundle for fever, hyperglycaemia and swallow management in a national audit for acute stroke: evidence of upscale and spread. Implement Sci 2019; 14: 87. PubMed PMC

Middleton S, Pfeilschifter W. International translation of fever, sugar, swallow protocols: the quality in acute stroke care Europe project. Int J Stroke 2020; 15: 591–594. PubMed

Zachrison KS, Dhand A, Schwamm LH, Onnela JP. A network approach to stroke systems of care. Circ Cardiovasc Qual Outcomes 2019; 12: e005526. PubMed PMC

Caso V, Zakaria MF, Tomek A, Martins S, Thang NH, Rossouw A. Improving stroke care across the world: the Angels Initiative. CNS 2018; 4: 32–42.

Hacke W, Brainin M, Caso V. The Angels Initiative: improving stroke care in Asia—proceedings of the WSO-ANGELS. CNS 2019; 5: 1–20.

Stroke Alliance for Europe (SAFE). Surviving stroke: helping to improving patient—doctor communication, https://www.safestroke.eu/safe-angels-initiative/ (2022, accessed 5 December 2022).

American Stroke Association. ASA forms new partnership, https://isc.hub.heart.org/isc-21/article/21330596/asa-forms-new-partnership (2021, accessed 4 July 2022).

World Stroke Organization. XXII Ibero-American Stroke Organization Congress and First WSO / IASO Angels award, https://www.world-stroke.org/news-and-blog/news/xxii-ibero-american-stroke-organization-congress-and-first-wso-iaso-angels-award-sept (2019, accessed 4 July 2022).

Hacke W, Caso V, Esagunde RU, Aref H, Martins SCO, Mikulik R. Stroke care taking flight with the wings of ANGELS. CNS 2021; 6: 8–25.

Boehringer Ingelheim. Angels Initiative won a PMEA award, https://www.angels-initiative.com/angels-community/stories/angels-initiative-won-pmea-award (2019, accessed 4 July 2022).

Boehringer Ingelheim. WSO Angels awards, https://www.angels-initiative.com/angels-awards/wso-award-winners (2022, accessed 4 July 2022).

Boehringer Ingelheim. WSO 2021 Diamond award, https://www.angels-initiative.com/content/WSO-2021-Diamond-Award (2022, accessed 11 January 2022).

Boehringer Ingelheim. Angels Initiative: data on file. Ingelheim am Rhein: Boehringer Ingelheim, 2022.

Aref H, Zakaria M, Shokri H, Roushdy T, El Basiouny A, El Nahas N. Changing the landscape of stroke in Egypt. Cerebrovasc Dis Extra 2021; 11: 155–159. PubMed PMC

Metabase. RES-Q live metrics, https://qualityregistry.eu/mb-aux/public/dashboard/78a1e97d-fe82-4aad-a229-f3044e9999d7 (2022, accessed 9 May 2022).

European Stroke Organisation. The Angels steering committee, https://eso-stroke.org/projects/angels/the-angels-steering-committee (2020, accessed 4 July 2022).

Boehringer Ingelheim. Meet the experts, https://www.angels-initiative.com/angels-community/european-steering-committee (2022, accessed 4 July 2022).

Boehringer Ingelheim. ESO Angels awards, https://www.angels-initiative.com/angels-awards/winners (2022, accessed 4 July 2022).

European Stroke Organisation. How to qualify for the ESO Angels Awards programme, https://eso-stroke.org/projects/angels/how-to-qualify-for-an-award/ (2020, accessed 4 July 2022).

Angels Initiative. EMS e-Learning, https://www.angels-initiative.com/content/ems-elearning (2020, accessed 27 September 2022).

Angels Initiative. EMS Awards: championing the providers of pre-hospital care, https://www.angels-initiative.com/angels-community/stories/ems-awards-championing-providers-pre-hospital-care (2021, accessed 27 September 2022).

Angels Initiative. FAST Heroes, https://www.world-stroke.org/world-stroke-day-campaign/world-stroke-campaign/fast-stroke-heroes (2022, accessed 27 September 2022).

Angels Initiative. FAST Heroes: about us, https://gb-en.fastheroes.com/about-2/ (2022, accessed 27 September 2022).

Middleton S, McElduff P, Ward J, et al. Implementation of evidence-based treatment protocols to manage fever, hyperglycaemia, and swallowing dysfunction in acute stroke (QASC): a cluster randomised controlled trial. Lancet 2011; 378: 1699–1706. PubMed

Middleton S, Lydtin A, Comerford D, et al. From QASC to QASCIP: successful Australian translational scale-up and spread of a proven intervention in acute stroke using a prospective pre-test/post-test study design. BMJ Open 2016; 6: e011568. PubMed PMC

Middleton S, Coughlan K, Mnatzaganian G, et al. Mortality reduction for fever, hyperglycemia, and swallowing nurse-initiated stroke intervention: QASC trial (quality in acute stroke care) follow-up. Stroke 2017; 48: 1331–1336. PubMed

Middleton S, Dale S, McElduff B, et al. Translation of nurse-initiated protocols to manage fever, hyperglycaemia and swallowing following stroke across Europe (QASC Europe): a pre-test/post-test implementation study. Eur Stroke J 2023; 8: 132–147. PubMed PMC

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...