Disulfide re-bridging reagents for single-payload antibody-drug conjugates
Jazyk angličtina Země Anglie, Velká Británie Médium electronic
Typ dokumentu časopisecké články
PubMed
37492000
PubMed Central
PMC10414422
DOI
10.1039/d3cc02980h
Knihovny.cz E-zdroje
- MeSH
- disulfidy MeSH
- imunokonjugáty * MeSH
- indikátory a reagencie MeSH
- protinádorové látky * MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- disulfidy MeSH
- imunokonjugáty * MeSH
- indikátory a reagencie MeSH
- protinádorové látky * MeSH
Numerous antibody-drug conjugate (ADC) linker technologies exist for the synthesis of ADCs with drug-to-antibody ratios (DARs) being an even integer (typically 2, 4 or 8). However, ADCs with odd-integer DARs are significantly harder to synthesise. Here, we report the synthesis of ADCs loaded with a single warhead, using TetraDVP linkers which simultaneously re-bridge all four interchain disulfides of an IgG1 antibody.
Apollo Therapeutics Ltd 50 60 Station Road Cambridge CB1 2JH UK
Yusuf Hamied Department of Chemistry University of Cambridge Cambridge CB2 1EW UK
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Tong J. T. W. Harris P. W. R. Brimble M. A. Kavianinia I. Molecules. 2021;26:5847. doi: 10.3390/molecules26195847. PubMed DOI PMC
ImmunoGen, ImmunoGen Announces FDA Accelerated Approval of ELAHERE (mirvetuximab soravtansine-gynx) for the Treatment of Platinum-Resistant Ovarian Cancer, https://investor.immunogen.com/news-releases/news-release-details/immunogen-announces-fda-accelerated-approval-elaheretm, (accessed 29 January 2023)
Hamblett K. J. Senter P. D. Chace D. F. Sun M. M. C. Lenox J. Cerveny C. G. Kissler K. M. Bernhardt S. X. Kopcha A. K. Zabinski R. F. Meyer D. L. Francisco J. A. Clin. Cancer Res. 2004;10:7063–7070. doi: 10.1158/1078-0432.CCR-04-0789. PubMed DOI
Walsh S. J. Bargh J. D. Dannheim F. M. Hanby A. R. Seki H. Counsell A. J. Ou X. Fowler E. Ashman N. Takada Y. Isidro-Llobet A. Parker J. S. Carroll J. S. Spring D. R. Chem. Soc. Rev. 2021;50:1305–1353. doi: 10.1039/D0CS00310G. PubMed DOI
Van Delft F. L., Van Geel R. and Wijdeven M. A., European Pat., EP2911699B1, 2017
White J. B. Fleming R. Masterson L. Ruddle B. T. Zhong H. Fazenbaker C. Strout P. Rosenthal K. Reed M. Muniz-Medina V. Howard P. Dixit R. Wu H. Hinrichs M. J. Gao C. Dimasi N. MAbs. 2019;11:515. doi: 10.1080/19420862.2019.1578611. PubMed DOI PMC
de Bever L. Popal S. van Schaik J. Rubahamya B. van Delft F. L. Thurber G. M. van Berkel S. S. Bioconjugate Chem. 2023;34:538–548. doi: 10.1021/acs.bioconjchem.2c00611. PubMed DOI PMC
Li X. Yang J. Rader C. Methods. 2014;65:133–138. doi: 10.1016/j.ymeth.2013.05.023. PubMed DOI PMC
Bruins J. J. Van De Wouw C. Wagner K. Bartels L. Albada B. Van Delft F. L. ACS Omega. 2019;4:11801–11807. doi: 10.1021/acsomega.9b01727. PubMed DOI PMC
Matsuda Y. Leung M. Okuzumi T. Mendelsohn B. Antibodies. 2020;9:16. doi: 10.3390/antib9020016. PubMed DOI PMC
Dovgan Igor. Hentz Alexandre. Koniev Oleksandr. Ehkirch Anthony. Hessmann Steve. Ursuegui Sylvain. Delacroix S. ébastien. Riomet Margaux. Taran Frédéric. Cianférani Sarah. Kolodych Sergii. Wagner Alain. Chem. Sci. 2020;11:1210–1215. doi: 10.1039/C9SC05468E. PubMed DOI PMC
Lee M. T. W. Maruani A. Richards D. A. Baker J. R. Caddick S. Chudasama V. Chem. Sci. 2017;8:2056–2060. doi: 10.1039/C6SC03655D. PubMed DOI PMC
Dannheim F. M. Walsh S. J. Orozco C. T. Hansen A. H. Bargh J. D. Jackson S. E. Bond N. J. Parker J. S. Carroll J. S. Spring D. R. Chem. Sci. 2022;13:8781–8790. doi: 10.1039/D2SC02198F. PubMed DOI PMC
