Synthesis of [3 H]Org24598 using in-house prepared [3 H]MeI
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
Grant support
RVO 61388963
Czech Academy of Sciences
PubMed
38221662
DOI
10.1002/jlcr.4084
Knihovny.cz E-resources
- Keywords
- COware gas reactor, GlyT1 inhibitor, [3H]Org24598, [3H]fluoxetine, [3H]methyl iodide preparation, [3H]methylation, [3H]thioanisol,
- MeSH
- Glycine * pharmacology analogs & derivatives MeSH
- Glycine Plasma Membrane Transport Proteins * MeSH
- Radiopharmaceuticals MeSH
- Tritium MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Glycine * MeSH
- org 24598 MeSH Browser
- Glycine Plasma Membrane Transport Proteins * MeSH
- Radiopharmaceuticals MeSH
- Tritium MeSH
The synthesis of tritium-labelled glycine transporter 1 inhibitor Org24598 is reported. Because of the instability of the Org24598 skeleton under hydrogenation conditions, a synthetic approach using an in-house prepared tritium-labelled alkylating agent ([3 H]MeI, SA = 26.2 Ci/mmol) was employed. Alternative methods of labelling are discussed.
See more in PubMed
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