A diagnostic algorithm for sinonasal papillary non-keratinizing squamous cell carcinoma with DEK::AFF2 fusion and mimickers
Language English Country Spain Media print-electronic
Document type Case Reports, Journal Article
PubMed
38246714
DOI
10.1016/j.patol.2023.08.002
PII: S1699-8855(23)00052-1
Knihovny.cz E-resources
- Keywords
- CSNE pobremente diferenciado no queratinizante, DEK::AFF2 fusion carcinoma, FISH, Fusión de DEK::AFF2 carcinoma, Poorly differentiated non-keratinizing SNSCC, Sinonasal,
- MeSH
- Algorithms MeSH
- Cell Differentiation MeSH
- Nuclear Proteins MeSH
- Middle Aged MeSH
- Humans MeSH
- Lymph Nodes MeSH
- Paranasal Sinus Neoplasms * diagnosis genetics MeSH
- Carcinoma, Squamous Cell * diagnosis genetics MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- AFF2 protein, human MeSH Browser
- Nuclear Proteins MeSH
Sinonasal carcinomas represent a rare and diverse group of tumors, presenting diagnostic complexities due to their varied histological and molecular features. To ensure accurate differentiation among these malignancies, a systematic and stepwise approach is paramount. Even with the morphological similarities between poorly differentiated (non) keratinizing sinonasal squamous cell carcinoma (SNSCC) and DEK::AFF2 SNSCC, the two lesions are distinguishable using the surrogate immunohistochemical marker AFF2 or molecular testing for DEK::AFF2 mutation. We report a rare case of SMARCB1-retained DEK::AFF2 papillary non-keratinizing SNSCC in a 53-year-old female, who presented with a polypoid mass corresponding to the left middle turbinate. Following the surgical resection of the tumor and locoregional lymph nodes, adjuvant radiotherapy was administered to eradicate any residual cancer cells that may have remained after surgery.
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