Working groups of the European LeukemiaNet have published several important consensus guidelines. Acute lymphoblastic leukemia (ALL) has many different clinical and biological subgroups and the knowledge on disease biology and therapeutic options is increasing exponentially. The European Working Group for Adult ALL has therefore summarized the current state of the art and provided comprehensive consensus recommendations for diagnostic approaches, biologic and clinical characterization, prognostic factors, and risk stratification as well as definitions of endpoints and outcomes. Aspects of treatment, management of subgroups and specific situations, aftercare, and supportive care are covered in a separate publication. The present recommendation intends to provide guidance for the initial management of adult patients with ALL and to define principles as a basis for future collaborative research.

Clinical Hematology Department Centre Hospitalier de Versailles Université Paris Saclay Versailles France

Clinical Hematology Department Institut Catala d'Oncologia Hospital Germans Trias 1 Pujol Josep Carreras Research Institute Badalona Spain

Department of Bone Marrow Transplantation and Onco Hematology Maria Sklodowska Curie National Research Institute of Oncology Gliwice Branch Gliwice Poland

Department of Internal Medicine Hematology and Oncology University Hospital Brno Brno Czech Republic

Department of Medicine 2 Hematology Oncology Goethe University University Hospital Frankfurt Germany

Division of Cancer and Genetics Cardiff University School of Medicine Cardiff United Kingdom

Division of Hematology Ospedale dell'Angelo Mestre Venice Italy

Erasmus MC Cancer Institute Rotterdam The Netherlands

Hematology Department of Translational and Precision Medicine Sapienza University Rome Italy

Hospital Saint Louis Assistance Publique Hôpitaux de Paris Paris France

IRCCS Istituto Romagnolo per lo Studio dei Tumori Dino Amadori Meldola Italy

Leukemia Department University Hospital Saint Louis Assistance Publique Hôpitaux de Paris Saint Louis Research Institute Université Paris Cité Paris France

Maladies du Sang University Hospital of Angers FHU Goal INSERM National Centre for Scientific Research Angers France

UCL Cancer Institute London United Kingdom

University Hospitals Bristol NHS Foundation Trust Bristol United Kingdom

References provided by Crossref.org