The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies. The use of less-conventional sampling strategies and integration of full-scan, high-resolution mass spectrometry and effect-directed analysis in environmental and human monitoring programmes have the potential to enhance the screening and identification of a wider range of chemicals of known, emerging or potential future concern. Here, we outline the key needs and recommendations identified within the European Partnership for Assessment of Risks from Chemicals (PARC) project for leveraging these innovative methodologies to support the development of next-generation chemical risk assessment.

ANSES French Agency for Food Environmental and Occupational Health and Safety Laboratory for Food Safety Pesticides and Marine Biotoxins Unit F 94701 Maisons Alfort France

ANSES French Agency for Food Environmental and Occupational Health and Safety Laboratory of Fougères Toxicology of Contaminants Unit 35306 Fougères France

ANSES French Agency for Food Environmental and Occupational Health and Safety Strategy and Programs Department F 94701 Maisons Alfort France

BRGM 3 avenue Claude Guillemin 45060 Orléans France

Environment and Health Department of Public Health and Primary Care Katholieke Universiteit of Leuven 1 Rue Louis Rech L 3555 Dudelange Luxembourg

Flanders Research Institute for Agriculture Fisheries And Food Brusselsesteenweg 370 9090 Melle Belgium

Flemish Institute for Technological Research Mol Belgium

German Environment Agency Laboratory for Water Analysis Colditzstraße 34 12099 Berlin Germany

Helmholtz Centre for Environmental Research GmbH UFZ Department of Effect Directed Analysis Permoserstraße 15 04318 Leipzig Germany

Helmholtz Centre for Environmental Research GmbH UFZ Department of Effect Directed Analysis Permoserstraße 15 04318 Leipzig Germany; Goethe University Frankfurt Department of Evolutionary Ecology and Environmental Toxicology Max von Laue Strasse 13 60438 Frankfurt Germany

INRAE French National Research Institute For Agriculture Food and Environment UR1454 EABX Bordeaux Metabolome MetaboHub Gazinet Cestas France

INRS Département Toxicologie et Biométrologie Laboratoire Biométrologie 1 rue du Morvan CS 60027 54519 Vandoeuvre Cedex France

Institute of Environmental Assessment and Water Research Barcelona Catalonia Spain

Institute of Legal Medicine and Core Facility Metabolomics Medical University of Insbruck 6020 Innsbruck Austria

Jožef Stefan Institute Department of Environmental Sciences Ljubljana Slovenia

Oniris INRAE LABERCA 44300 Nantes France

RECETOX Faculty of Science Masaryk University Kotlarska 2 Brno Czech Republic

RECETOX Faculty of Science Masaryk University Kotlarska 2 Brno Czech Republic; Jožef Stefan Institute Department of Environmental Sciences Ljubljana Slovenia

Swiss Federal Institute of Aquatic Science and Technology Eawag 8600 Dübendorf Switzerland; Institute of Biogeochemistry and Pollutant Dynamics ETH Zürich 8092 Zürich Switzerland

Toxalim Toulouse France

Toxicological Center University of Antwerp 2610 Wilrijk Belgium

Unit Environmental Hygiene and Human Biological Monitoring Department of Health Protection Laboratoire National de Santé 3000 Leuven Belgium

Unit Medical Expertise and Data Intelligence Department of Health Protection Laboratoire National de Santé 1 Rue Louis Rech L 3555 Dudelange Luxembourg

Univ Rennes Inserm EHESP Irset UMR_S 1085 Rennes France

University of Ljubljana Faculty of Pharmacy Slovenia

Vrije Universiteit Amsterdam Amsterdam Institute for Life and Environment Section Chemistry for Environment and Health De Boelelaan 1085 1081 HV Amsterdam The Netherlands

Vrije Universiteit Amsterdam Amsterdam Institute for Life and Environment Section Chemistry for Environment and Health De Boelelaan 1085 1081 HV Amsterdam The Netherlands; KWR Water Research Institute Nieuwegein The Netherlands

Wageningen Food Safety Research Part of Wageningen University and Research Akkermaalsbos 2 6708 WB Wageningen The Netherlands

References provided by Crossref.org

High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage