Anabolic steroids induced changes at the level of protein expression: Effects of prolonged administration of testosterone and nandrolone to pigs
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
38521435
DOI
10.1016/j.etap.2024.104422
PII: S1382-6689(24)00062-0
Knihovny.cz E-resources
- Keywords
- drugs, histology, muscle, proteomics, testes,
- MeSH
- Anabolic Androgenic Steroids * toxicity MeSH
- Nandrolone * toxicity MeSH
- Swine MeSH
- Testosterone MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anabolic Androgenic Steroids * MeSH
- Nandrolone * MeSH
- Testosterone MeSH
Synthetic derivatives of steroid hormones, specifically anabolic-androgenic steroids (AAS), have gained prominence due to their observed benefits in enhancing meat quality. The study replicated the administration of banned AAS and investigated their impacts on pigs to contribute to the understanding of animal biochemistry and to explore the feasibility of detecting AAS administration by employing a non-targeted analysis. The effects were corroborated by evaluating changes in the expression of selected proteins, as well as examining haematological and biochemical profiles and histological alterations. Exposure to AAS influenced the expression of proteins related to drug-metabolizing enzymes, muscle and lipid metabolism, kidney function, reproductive processes, immune system functions, and carcinogenic changes. The effects of AAS appear intricate and contingent on factors such as the specific drug used, dosage, and duration of administration. The results underscore that protein expression analysis holds promise as a valuable tool for detecting illicit AAS use in the fattening process.
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