Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czech Republic

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Pachon JC, Pachon EI, Pachon JC, et al. “Cardioneuroablation”–new treatment for neurocardiogenic syncope, functional AV block and sinus dysfunction using catheter RF‐ablation. EP Europace. 2005;7(1):1‐13.

Lazzara R, Scherlag BJ, Robinson MJ, Samet P. Selective in situ parasympathetic control of the canine sinoatrial and atrioventricular nodes. Circ Res. 1973;32:393‐401.

Schauerte P, Scherlag BJ, Patterson E, et al. Focal atrial fibrillation: experimental evidence for a pathophysiologic role of the autonomic nervous system. J Cardiovasc Electrophysiol. 2001;12:592‐599.

Pachon M JC, Pachon M EI, Pachon M JC, et al. A new treatment for atrial fibrillation based on spectral analysis to guide the catheter RF ablation. Europace. 2004;6:590‐601.

Pachon JC, Pachon EI, Cunha Pachon MZ, Lobo TJ, Pachon JC, Santillana P TG. Catheter ablation of severe neurally meditated reflex (neurocardiogenic or vasovagal) syncope: cardioneuroablation long‐term results. Europace. 2011;13(9):1231‐1242.

Scherlag BJ, Nakagawa H, Jackman WM, et al. Electrical stimulation to identify neural elements on the heart: their role in atrialfibrillation. J Interv Card Electrophysiol. 2005;13(suppl 1):37‐42.

Lu Z, Scherlag BJ, Lin J, et al. Autonomic mechanism for complex fractionated atrial electrograms: evidence by fast Fourier transform analysis. J Cardiovasc Electrophysiol. 2008;19(8):835‐842.

Katritsis D, Giazitzoglou E, Sougiannis D, Goumas N, Paxinos G, Camm AJ. Anatomic approach for ganglionic plexi ablation in patients with paroxysmal atrial fibrillation. Am J Cardiol. 2008;102(3):330‐334.

Yao Y, Shi R, Wong T, et al. Endocardial autonomic denervation of the left atrium to treat vasovagal syncope: an early experience in humans. Circul Arrhythm Electrophysiol. 2012;5(2):279‐286.

Aksu T, Golcuk SE, Erdem Guler T, Yalin K, Erden I. Functional permanent 2:1 atrioventricular block treated with cardioneuroablation: case report. HeartRhythm Case Rep. 2015;1(2):58‐61.

Rivarola E, Hardy C, Sosa E, et al. Selective atrial vagal denervation guided by spectral mapping to treat advanced atrioventricular block. Europace. 2016;18(3):445‐449.

Aksu T, Baysal E, Guler TE, Yalın K. Selective right atrial cardioneuroablation in functional atrioventricular block. Europace. 2017;19(2):333.

Roubicek T, Wichterle D, Kautzner J. Cardioneuroablation in a patient with atrioventricular nodal re‐entrant tachycardia. EP Europace. 2018;20(12):2044.

Fukunaga M, Wichterle D, Peichl P, Aldhoon B, Čihák R, Kautzner J. Differential effect of ganglionic plexi ablation in a patient with neurally mediated syncope and intermittent atrioventricular block. Europace. 2017;19(1):119‐126.

Sun W, Zheng L, Qiao Y, et al. Catheter ablation as a treatment for vasovagal syncope: long‐term outcome of endocardial autonomic modification of the left atrium. J Am Heart Assoc. 2016;5(7):e003471.

Aksu T, Guler TE, Mutluer FO, Bozyel S, Golcuk SE, Yalin K. Electroanatomic‐mapping‐guided cardioneuroablation versus combined approach for vasovagal syncope: a cross‐sectional observational study. J Interv Card Electrophysiol. 2019;54(2):177‐188.

Piotrowski R, Baran J, Kułakowski P. Cardioneuroablation using an anatomical approach: a new and promising method for the treatment of cardioinhibitory neurocardiogenic syncope. Kardiol Pol. 2018;76(12):1736‐1738.

Debruyne P, Rossenbacker T, Collienne C, et al. Unifocal right‐sided ablation treatment for neurally mediated syncope and functional sinus node dysfunction under computed tomographic guidance. Circul Arrhythm Electrophysiol. 2018;11(9):e006604.

Hu F, Zheng L, Liang E, et al. Right anterior ganglionated plexus: the primary target of cardioneuroablation? Heart Rhythm. 2019;16:1545‐1551.

Maj R, Osório TG, Borio G, et al. A novel strategy to treat vaso‐vagal syncope: cardiac neuromodulation by cryoballoon pulmonary vein isolation. Indian Pacing Electrophysiol J. 2020;20(4):154‐159.

Calo L, Rebecchi M, Sette A, et al. Catheter ablation of right atrial ganglionated plexi to treat cardioinhibitory neurocardiogenic syncope: a long‐term follow‐up prospective study. J Interv Card Electrophysiol. 2021;61(3):499‐510.

Aksu T, Padmanabhan D, Shenthar J, et al. The benefit of cardioneuroablation to reduce syncope recurrence in vasovagal syncope patients: a case‐control study. J Interv Card Electrophysiol. 2022;63(1):77‐86.

Piotrowski R, Baran J, Sikorska A, Krynski T, Kulakowski P. Cardioneuroablation for reflex syncope: efficacy and effects on autonomic cardiac regulation‐a prospective randomized trial. JACC: Clin Electrophysiol. 2023;9:85‐95.

Stirrup J, Gregg S, Baavour R, et al. Hybrid solid‐state SPECT/CT left atrial innervation imaging for identification of left atrial ganglionated plexi: technique and validation in patients with atrial fibrillation. J Nucl Cardiol. 2020;27(6):1939‐1950.

Pachon M. JC, Pachon M. EI, Santillana P. TG, et al. Simplified method for vagal effect evaluation in cardiac ablation and electrophysiological procedures. JACC: Clin Electrophysiol. 2015;1:451‐460.

Wichterle D, Jansová H, Štiavnický P, et al. Cardioneuroablation focused on the atrioventricular node: a comparison of right and left atrial approach (abstract). Eur Heart J. 2022;43:656.

Štiavnický P, Wichterle D, Jansová H, et al. Importance of bilateral vagus nerve stimulation for effective atrioventricular node denervation during cardioneuroablation. Eur Heart J. 2022;43:ehac544.654.

Pachon‐M JC, Pachon‐M EI, Pachon CTC, et al. Long‐term outcomes of cardioneuroablation with and without extra‐cardiac vagal stimulation confirmation in severe cardioinhibitory neurocardiogenic syncope. J Cardiovasc Electrophysiol. 2024;35(4):641‐650. doi:10.1111/jce.16188

Stojadinović P, Wichterle D, Peichl P, et al. Autonomic changes are more durable after radiofrequency than pulsed electric field pulmonary vein ablation. JACC: Clin Electrophysiol. 2022;8(7):895‐904.