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Comparison of outcomes of immunosuppressive therapy with rabbit versus horse antithymocyte globulin and cyclosporine a in children with acquired severe aplastic anemia

. 2024 Jul ; 99 (7) : 1403-1406. [epub] 20240415

Language English Country United States Media print-electronic

Document type Letter, Comparative Study, Research Support, Non-U.S. Gov't

Grant support
Parent Association in Freiburg

Bone Marrow Transplantation Unit Detská fakultná nemocnica s poliklinikou v Bratislave Bratislava Slovakia

Department of Hematology Oncology and Stemcell Transplantation University Children's Hospital Zurich Switzerland

Department of Paediatric Haematology and Oncology 2nd Faculty of Medicine Charles University and University Hospital Motol Prague Czech Republic

Department of Paediatric Transplantology Haematology and Oncology Warsaw Medical University Warsaw Poland

Department of Pediatric Hematology and Oncology IRCCS Ospedale Pediatrico Bambino Gesù Catholic University of the Sacred Hearth Rome Italy

Department of Pediatric Hematology and Oncology Oslo University Hospital Oslo Norway

Department of Pediatric Hematology and Oncology University Hospital Leuven Gasthuisberg Leuven Belgium

Department of Pediatric Hematology Oncology Aghia Sophia Children's Hospital Athens Greece

Department of Pediatrics and Adolescent Medicine Division of Pediatric Hematology and Oncology Medical Center Faculty of Medicine University of Freiburg Freiburg Germany

Department of Stem Cell Transplantation Princess Máxima Center for Pediatric Oncology and Wilhelmina Children's Hospital Utrecht The Netherlands

Dept of Pediatric Hematology and Stem Cell Transplantation Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases Budapest Hungary

Division of Hematology Oncology and SCT Children's Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland

Hematology and Hemotherapy Unit Hospital Infantil Universitario Niño Jesús Madrid Spain

National Children's Cancer Service Children's Health Ireland Dublin Ireland

Pediatric Hematology Unit Hospital Dona Estefânia Centro Hospitalar Universitário de Lisboa Central Lisbon Portugal

Pediatric Hematopoietic Stem Cell Transplantation and Immunodeficiency The Child and Adolescent Department Rigshospitalet Copenhagen University Hospital Copenhagen Denmark

St Anna Children's Hospital Department of Pediatrics Medical University of Vienna and St Anna Children's Cancer Research Institute Vienna Austria

Unit of Oncology and Haematology University Children's Hospital Ljubljana University Medical Centre Ljubljana Slovenia

See more in PubMed

Marsh JC, Bacigalupo A, Schrezenmeier H, et al. Prospective study of rabbit antithymocyte globulin and cyclosporine for aplastic anemia from the EBMT severe aplastic Anaemia working party. Blood. 2012;119(23):5391‐5396.

Scheinberg P, Nunez O, Weinstein B, et al. Horse versus rabbit antithymocyte globulin in acquired aplastic anemia. N Engl J Med. 2011;365(5):430‐438.

Yoshimi A, Niemeyer CM, Fuhrer MM, Strahm B. Comparison of the efficacy of rabbit and horse antithymocyte globulin for the treatment of severe aplastic anemia in children. Blood. 2013;121(5):860‐861.

Yoshimi A, van den Heuvel‐Eibrink MM, Baumann I, et al. Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood. Haematologica. 2014;99(4):656‐663.

Peffault de Latour R, Kulasekararaj A, Iacobelli S, et al. Eltrombopag added to immunosuppression in severe aplastic anemia. N Engl J Med. 2022;386(1):11‐23.

Yagasaki H, Shichino H, Ohara A, et al. Immunosuppressive therapy with horse anti‐thymocyte globulin and cyclosporine as treatment for fulminant aplastic anemia in children. Ann Hematol. 2014;93(5):747‐752.

Groarke EM, Patel BA, Gutierrez‐Rodrigues F, et al. Eltrombopag added to immunosuppression for children with treatment‐naive severe aplastic anaemia. Br J Haematol. 2021;192(3):605‐614.

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