Mitochondria, the powerhouse and the vital signaling hub of the cell, participate in a variety of biological processes, such as apoptosis, redox responses, cell senescence, autophagy, and iron homeostasis. Mitochondria form a mostly tubular network, made up of an outer and a cristeae-forming inner membrane. The network undergoes dynamic fusion and fission that change its morphological structure according to the functional needs. Approximately 1500 mitochondrial proteins encoded by nuclear genome plus over 10 proteins encoded by mitochondrial DNA are folded and assembled in the mitochondria under a high-fidelity control system. These proteins are involved in oxidative phosphorylation, metabolism, network and cristae dynamics, mitophagy, import machinery, ion channels, and mitochondrial DNA maintenance. This Collection gathers original research that advances our understanding of the monitoring techniques and pathophysiological significance of mitochondrial dynamics in health and disease.

Center for Molecular Medicine and Genetics Wayne State University School of Medicine Detroit MI 48201 USA

Department of Biochemistry Microbiology and Immunology Wayne State University School of Medicine Detroit MI 48201 USA

Laboratory of Mitochondrial Physiology Institute of Physiology of the Czech Academy of Sciences Vídeňská 1083 14220 Prague Czech Republic

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Smith HE, et al. The use of NADH anisotropy to investigate mitochondrial cristae alignment. Sci. Rep. 2024;14:5980. doi: 10.1038/s41598-024-55780-5. PubMed DOI PMC

Koller A, et al. Nuclear and mitochondrial genetic variants associated with mitochondrial DNA copy number. Sci. Rep. 2024;14:2083. doi: 10.1038/s41598-024-52373-0. PubMed DOI PMC

Tarallo D, et al. Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy. Sci. Rep. 2024;14:909. doi: 10.1038/s41598-024-51427-7. PubMed DOI PMC

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