Exploring the Disparity in Indoor/Outdoor Time and Radon Exposure as Possible Factors Contributing to the Unexpected Increase in Lung Cancer Risk among Non-Smoking Women
Status PubMed-not-MEDLINE Jazyk angličtina Země Írán Médium electronic-ecollection
Typ dokumentu časopisecké články
PubMed
39175557
PubMed Central
PMC11336053
DOI
10.31661/jbpe.v0i0.2312-1701
PII: JBPE-14-4
Knihovny.cz E-zdroje
- Klíčová slova
- Gender, Indoor/Outdoor Time, Lung Neoplasms, Radon, Smoking, Women,
- Publikační typ
- časopisecké články MeSH
According to a NIH study, Lung cancer among individuals who have never smoked is more prevalent in women and occurs at an earlier age than in smokers. The rise in lung cancer rates among female non-smokers might be linked to radon inhalation and should be further investigated. Our theory is based on the differences in radon exposure between males and females, which can be attributed to the variations in time spent indoors versus outdoors. Over the past few years, the smoking rates have shown a steady decline in the United States and other developed countries. This decrease in smoking prevalence has led to a new shift in the primary risk factors associated with lung cancer. Although tobacco smoke historically served as the primary cause of lung cancer, the reduction in smoking rates has allowed other risk factors, such as radon exposure, to come to the forefront. Given that women in certain countries, on average, might spend more time indoors compared to men, they are potentially exposed to higher levels of radon. This increased exposure could explain the rising rates of lung cancer among female non-smokers. The theory is still in its nascent stages and requires further research and validation. However, if proven correct, it could significantly alter our understanding of lung cancer risk factors and lead to new prevention. It is therefore crucial to expedite the review and publication of this theory, given its potential implications for public health.
Department of Physics East Carolina University Greenville NC 27858 USA
Department of Radiation Dosimetry Nuclear Physics Institute of the CAS 25068 Prague Czech Republic
Department of Radiation Physics Technische Universität Wien Atominstitut 1040 Vienna Austria
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Schabath MB, Cote ML. Cancer Progress and Priorities: Lung Cancer. Cancer Epidemiol Biomarkers Prev. 2019;28(10):1563–79. doi: 10.1158/1055-9965.EPI-19-0221. [ PMC Free Article ] PubMed DOI PMC
Jemal A, Miller KD, Ma J, Siegel RL, Fedewa SA, Islami F, et al. Higher Lung Cancer Incidence in Young Women than Young Men in the United States. N Engl J Med. 2018;378(21):1999–2009. doi: 10.1056/NEJMoa1715907. [ PMC Free Article ] PubMed DOI PMC
Fidler-Benaoudia MM, Torre LA, Bray F, Ferlay J, Jemal A. Lung cancer incidence in young women vs. young men: A systematic analysis in 40 countries. Int J Cancer. 2020;147(3):811–9. doi: 10.1002/ijc.32809. PubMed DOI
Khazaei Z, Sohrabivafa M, Momenabadi V, Moayed L, Goodarzi E. Global cancer statistics 2018: Globocan estimates of incidence and mortality worldwide prostate cancers and their relationship with the human development index. Advances in Human Biology. 2019;9(3):245–50. doi: 10.4103/2321-8568.262891. DOI
Lee YS. Gender differences in physical activity and walking among older adults. J Women Aging. 2005;17(1-2):55–70. doi: 10.1300/J074v17n01_05. PubMed DOI
Bonsang E, Van Soest A. Time devoted to home production and retirement in couples: a panel data analysis. Labour Economics. 2020;65:101810. doi: 10.1016/j.labeco.2020.101810. DOI
Lee S. Falls associated with indoor and outdoor environmental hazards among community-dwelling older adults between men and women. BMC Geriatr. 2021;21(1):547. doi: 10.1186/s12877-021-02499-x. [ PMC Free Article ] PubMed DOI PMC
Lortet-Tieulent J, Soerjomataram I, Ferlay J, Rutherford M, Weiderpass E, Bray F. International trends in lung cancer incidence by histological subtype: adenocarcinoma stabilizing in men but still increasing in women. Lung Cancer. 2014;84(1):13–22. doi: 10.1016/j.lungcan.2014.01.009. PubMed DOI
Meza R, Meernik C, Jeon J, Cote ML. Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010. PLoS One. 2015;10(3):e0121323. doi: 10.1371/journal.pone.0121323. [ PMC Free Article ] PubMed DOI PMC
Chapman AM, Sun KY, Ruestow P, Cowan DM, Madl AK. Lung cancer mutation profile of EGFR, ALK, and KRAS: Meta-analysis and comparison of never and ever smokers. Lung Cancer. 2016;102:122–34. doi: 10.1016/j.lungcan.2016.10.010. PubMed DOI
Howlader N, Noone AM, Krapcho M, Miller D, Brest A, Yu M, et al. SEER cancer statistics review, 1975–2018. National Cancer Institute. 2021:1–25.
Titan AL, Baiu I, Liou D, Lui NS, Berry M, Shrager J, Backhus L. Eligibility for Lung Cancer Screening Among Women Receiving Screening for Breast Cancer. JAMA Netw Open. 2022;5(9):e2233840. doi: 10.1001/jamanetworkopen.2022.33840. [ PMC Free Article ] PubMed DOI PMC
Toh CK, Ong WS, Lim WT, Tan DS, Ng QS, Kanesvaran R, et al. A Decade of Never-smokers Among Lung Cancer Patients-Increasing Trend and Improved Survival. Clin Lung Cancer. 2018;19(5):e539–50. doi: 10.1016/j.cllc.2018.03.013. PubMed DOI
Jones JM. Cigarette Smoking Rates Down Sharply Among U.S. Young Adults. News; 2022.
Bryant A, Cerfolio RJ. Differences in epidemiology, histology, and survival between cigarette smokers and never-smokers who develop non-small cell lung cancer. Chest. 2007;132(1):185–92. doi: 10.1378/chest.07-0442. PubMed DOI
Lorenzo-González M, Torres-Durán M, Barbosa-Lorenzo R, Provencio-Pulla M, Barros-Dios JM, Ruano-Ravina A. Radon exposure: a major cause of lung cancer. Expert Rev Respir Med. 2019;13(9):839–50. doi: 10.1080/17476348.2019.1645599. PubMed DOI
Beyer KMM, Szabo A, Hoormann K, Stolley M. Time spent outdoors, activity levels, and chronic disease among American adults. J Behav Med. 2018;41(4):494–503. doi: 10.1007/s10865-018-9911-1. [ PMC Free Article ] PubMed DOI PMC
Yuen HK, Jenkins GR. Factors associated with changes in subjective well-being immediately after urban park visit. Int J Environ Health Res. 2020;30(2):134–45. doi: 10.1080/09603123.2019.1577368. PubMed DOI
Gökmen A, Gökmen IG, Hung YT. Radon pollution control. In: Advanced Air and Noise Pollution Control. Totowa, New Jersey: Humana Press Inc; 2005. pp. 335–57.
Somsunun K, Prapamontol T, Pothirat C, Liwsrisakun C, Pongnikorn D, Fongmoon D, et al. Estimation of lung cancer deaths attributable to indoor radon exposure in upper northern Thailand. Sci Rep. 2022;12(1):5169. doi: 10.1038/s41598-022-09122-y. [ PMC Free Article ] PubMed DOI PMC
Abbasi S, Mortazavi SAR, Mortazavi SMJ. Martian Residents: Mass Media and Ramsar High Background Radiation Areas. J Biomed Phys Eng. 2019;9(4):483–6. doi: 10.31661/jbpe.v0i0.1138. [ PMC Free Article ] PubMed DOI PMC
Mortazavi SMJ, Mortazavi Gh, Mortazavi SAR, Paknahad M. Is Induction of Anomalies in Lymphocytes of the Residents of High Background Radiation Areas Associated with Increased Cancer Risk? J Biomed Phys Eng. 2019;9(3):367–72. doi: 10.31661/jbpe.v9i3Jun.654. [ PMC Free Article ] PubMed DOI PMC
Mortazavi SMJ, Jamali F, Moradgholi J, Mehdizadeh AR, Faghihi R, Mehdizadeh S, et al. Investigation of the Efficacy of Damp-Proof Montmorillonite Nanoclay for Radon Reduction Strategies in Radon Prone Areas of Ramsar. J Biomed Phys Eng. 2013;3(1):25–8.
Haghani M, Mortazavi SMJ, Faghihi R, Mehdizadeh S, Moradgholi J, Darvish L, et al. Nanomaterial containing wall paints can increase radon concentration in houses located in radon prone areas. J Biomed Phys Eng. 2013;3(3):105–8. [ PMC Free Article ] PubMed PMC