BACKGROUND: Although illness perception (IP) is a widely recognised factor in the psychosocial adjustment to cancer, little is known about the impact of individual dimensions of IP. This study aims to analyse the relationship between individual dimensions of IP and quality of life (QOL) in childhood cancer survivors. METHODS: The sample consisted of 163 long-term survivors aged 11 to 25 who were administered the Brief Illness Perceptions Questionnaire and the Minneapolis-Manchester Quality of Life Scale. RESULTS: In the correlational analysis, all dimensions of IP were associated with individual dimensions of QOL, except for understanding and treatment control. The results of the hierarchical regression analysis controlling for demographic and medical factors showed that IP had predicted individual dimensions of QOL above and beyond these factors, with emotional response, concern, consequences and understanding being the most predictive dimensions. Several age-specific relationships between IP and QOL were also identified. CONCLUSIONS: Illness perceptions significantly contribute to explaining QOL of childhood cancer survivors above and beyond demographic and medical factors. These results may contribute to more effective targeting of psychosocial interventions promoting QOL of survivors.

Department of Psychology Faculty of Arts Masaryk University 602 00 Brno Czech Republic

Institute of Psychology Czech Academy of Sciences 602 00 Brno Czech Republic

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Ward E., DeSantis C., Robbins A., Kohler B., Jemal A. Childhood and Adolescent Cancer Statistics, 2014. CA. Cancer J. Clin. 2014;64:83–103. doi: 10.3322/caac.21219. PubMed DOI

SEER*Explorer Application. [(accessed on 5 December 2023)]; Available online: https://seer.cancer.gov/statistics-network/explorer/application.html?site=1&data_type=1&graph_type=2&compareBy=sex&chk_sex_1=1&rate_type=2&race=1&age_range=15&hdn_stage=101&advopt_precision=1&advopt_show_ci=on&advopt_show_count=on&hdn_view=0&advopt_show_apc=on&advopt_display=1.

Czech Childhood Cancer Information System. [(accessed on 5 December 2023)]. Available online: https://ccc-is.uzis.cz/browser/web/cs/survival/?submenu=by_year&type=0&sex=0&age-category=2&group-years=false&method=13.

Klassen A.F., Anthony S.J., Khan A., Sung L., Klaassen R. Identifying Determinants of Quality of Life of Children with Cancer and Childhood Cancer Survivors: A Systematic Review. Support. Care Cancer. 2011;19:1275–1287. doi: 10.1007/s00520-011-1193-x. PubMed DOI

Schulte F., Russell K.B., Cullen P., Embry L., Fay-McClymont T., Johnston D., Rosenberg A.R., Sung L. Systematic Review and Meta-Analysis of Health-Related Quality of Life in Pediatric CNS Tumor Survivors. Pediatr. Blood Cancer. 2017;64:e26442. doi: 10.1002/pbc.26442. PubMed DOI

Stokke J., Sung L., Gupta A., Lindberg A., Rosenberg A.R. Systematic Review and Meta-Analysis of Objective and Subjective Quality of Life among Pediatric, Adolescent, and Young Adult Bone Tumor Survivors. Pediatr. Blood Cancer. 2015;62:1616–1629. doi: 10.1002/pbc.25514. PubMed DOI PMC

Leventhal H., Phillips L.A., Burns E. The Common-Sense Model of Self-Regulation (CSM): A Dynamic Framework for Understanding Illness Self-Management. J. Behav. Med. 2016;39:935–946. doi: 10.1007/s10865-016-9782-2. PubMed DOI

Hagger M.S., Orbell S. A Meta-Analytic Review of the Common-Sense Model of Illness Representations. Psychol. Health. 2003;18:141–184. doi: 10.1080/088704403100081321. DOI

Richardson E.M., Schüz N., Sanderson K., Scott J.L., Schüz B. Illness Representations, Coping, and Illness Outcomes in People with Cancer: A Systematic Review and Meta-Analysis. Psycho-Oncology. 2017;26:724–737. doi: 10.1002/pon.4213. PubMed DOI

Broadbent E., Wilkes C., Koschwanez H., Weinman J., Norton S., Petrie K.J. A Systematic Review and Meta-Analysis of the Brief Illness Perception Questionnaire. Psychol. Health. 2015;30:1361–1385. doi: 10.1080/08870446.2015.1070851. PubMed DOI

Asnani M.R., Barton-Gooden A., Grindley M., Knight-Madden J. Disease Knowledge, Illness Perceptions, and Quality of Life in Adolescents with Sickle Cell Disease: Is There a Link? Glob. Pediatr. Health. 2017;4:1–10. doi: 10.1177/2333794X17739194. PubMed DOI PMC

Fischer M.J., Ketelaar M., Van Der Veere P.J., Verhoef M., Wadman R.I., Visser-Meily J.M.A., Van Der Pol W.L., Schröder C.D. Illness Perceptions in Pediatric Spinal Muscular Atrophy: Agreement between Children and Their Parents, and Its Association with Quality of Life. J. Dev. Phys. Disabil. 2021;33:297–310. doi: 10.1007/s10882-020-09749-7. DOI

Scharloo M., Baatenburg De Jong R.J., Langeveld T.P.M., Van Velzen-Verkaik E., Doorn-op Den Akker M.M., Kaptein A.A. Quality of Life and Illness Perceptions in Patients with Recently Diagnosed Head and Neck Cancer. Head Neck. 2005;27:857–863. doi: 10.1002/hed.20251. PubMed DOI

Stapersma L., Van Den Brink G., Van Der Ende J., Bodelier A.G., Van Wering H.M., Hurkmans P.C.W.M., Mearin M.L., Van Der Meulen–de Jong A.E., Escher J.C., Utens E.M.W.J. Illness Perceptions and Depression Are Associated with Health-Related Quality of Life in Youth with Inflammatory Bowel Disease. Int. J. Behav. Med. 2019;26:415–426. doi: 10.1007/s12529-019-09791-6. PubMed DOI PMC

de Rooij B.H., Thong M.S.Y., van Roij J., Bonhof C.S., Husson O., Ezendam N.P.M. Optimistic, Realistic, and Pessimistic Illness Perceptions; Quality of Life; and Survival among 2457 Cancer Survivors: The Population-Based PROFILES Registry. Cancer. 2018;124:3609–3617. doi: 10.1002/cncr.31634. PubMed DOI

Dempster M., McCorry N.K., Brennan E., Donnelly M., Murray L.J., Johnston B.T. Illness Perceptions among Carer–Survivor Dyads Are Related to Psychological Distress among Oesophageal Cancer Survivors. J. Psychosom. Res. 2011;70:432–439. doi: 10.1016/j.jpsychores.2010.07.007. PubMed DOI

Schoormans D., Wijnberg L., Haak H., Husson O., Mols F. Negative Illness Perceptions Are Related to Poorer Health-Related Quality of Life among Thyroid Cancer Survivors: Results from the PROFILES Registry. Head Neck. 2020;42:2533–2541. doi: 10.1002/hed.26290. PubMed DOI PMC

Fonseca M., Missotten P., Etienne A.-M., Dupuis G., Lemétayer F., Spitz E. The Impact of Children’s Illness Perceptions on Paediatric Cancer Patients’ Quality of Life. Psycho-Oncology. 2010;19:126.

Herzog K., Schepper F., Pletschko T., Herrmann J., Budich M., Christiansen H., Suttorp M., Martini J. Illness Perceptions, Fear of Progression and Health-Related Quality of Life during Acute Treatment and Follow-up Care in Paediatric Cancer Patients and Their Parents: A Cross-Sectional Study. BMC Psychol. 2023;11:44. doi: 10.1186/s40359-023-01078-6. PubMed DOI PMC

Husson O., Poort H., Sansom-Daly U.M., Netea-Maier R., Links T., Mols F. Psychological Distress and Illness Perceptions in Thyroid Cancer Survivors: Does Age Matter? J. Adolesc. Young Adult Oncol. 2020;9:375–383. doi: 10.1089/jayao.2019.0153. PubMed DOI

Bhatia S., Jenney M.E.M., Wu E., Bogue M.K., Rockwood T.H., Feusner J.H., Friedman D.L., Robison L.L., Kane R.L. The Minneapolis-Manchester Quality of Life Instrument: Reliability and Validity of the Youth Form. J. Pediatr. 2004;145:39–46. doi: 10.1016/j.jpeds.2004.02.034. PubMed DOI

Bhatia S., Jenney M.E.M., Bogue M.K., Rockwood T.H., Feusner J.H., Friedman D.L., Robison L.L., Kane R.L. The Minneapolis-Manchester Quality of Life Instrument: Reliability and Validity of the Adolescent Form. J. Clin. Oncol. 2002;20:4692–4698. doi: 10.1200/JCO.2002.05.103. PubMed DOI

Broadbent E., Petrie K.J., Main J., Weinman J. The Brief Illness Perception Questionnaire. J. Psychosom. Res. 2006;60:631–637. doi: 10.1016/j.jpsychores.2005.10.020. PubMed DOI

Trizano-Hermosilla I., Alvarado J.M. Best Alternatives to Cronbach’s Alpha Reliability in Realistic Conditions: Congeneric and Asymmetrical Measurements. Front. Psychol. 2016;7:769. doi: 10.3389/fpsyg.2016.00769. PubMed DOI PMC

Bibace R., Walsh M.E. Development of Children’s Concepts of Illness. Pediatrics. 1980;66:912–917. doi: 10.1542/peds.66.6.912. PubMed DOI

Harris R.J. A Primer of Multivariate Statistics. 3rd ed. Psychology Press; New York, NY, USA: 2001.

Krull K.R., Hardy K.K., Kahalley L.S., Schuitema I., Kesler S.R. Neurocognitive Outcomes and Interventions in Long-Term Survivors of Childhood Cancer. J. Clin. Oncol. 2018;36:2181–2189. doi: 10.1200/JCO.2017.76.4696. PubMed DOI PMC

Sonney J.T., Insel K.C. Reformulating the Common Sense Model of Self-Regulation. Nurs. Sci. Q. 2016;29:154–159. doi: 10.1177/0894318416630091. PubMed DOI

Herzog K., Schepper F., Kamm R., Engelhardt-Lohrke C., Kreisch A., Pletschko T., Hauer J., Christiansen H., Suttorp M., Kiel J., et al. Illness Perceptions in Patients and Parents in Paediatric Oncology during Acute Treatment and Follow-up Care. Psycho-Oncology. 2022;31:950–959. doi: 10.1002/pon.5883. PubMed DOI

Szentes A., Kökönyei G., Békési A., Bokrétás I., Török S. Differences in Illness Perception between Children with Cancer and Other Chronic Diseases and Their Parents. Clin. Child Psychol. Psychiatry. 2017;23:365–380. doi: 10.1177/1359104517731899. PubMed DOI