C-Peptide [C-peptid]
topical
157
- Terms
-
C-Peptide, Proinsulin
Connecting Peptide
Proinsulin C-Peptide
Persistent link
https://www.medvik.cz/link/D002096
Definition
The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
- Annotation
- from proinsulin only: not for peptide fragments from other proteins ( = PEPTIDE FRAGMENTS)
- DUI
- D002096 MeSH Browser
- CUI
- M0003121
- Previous indexing
- Peptides (1973-1976); Proinsulin (1975-1976)
- History note
- 84(77); was see under PEPTIDES 1977-83
- Public note
- 84; was see under PEPTIDES 1977-83
Allowable subheadings
- AD
- administration & dosage 1
- AE
- adverse effects 0
- AG
- agonists 0
- AN
- analysis 26
- AI
- antagonists & inhibitors 0
- BI
- biosynthesis 2
- BL
- blood 78
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 1
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 3
- EC
- economics 0
- GE
- genetics 1
- HI
- history 2
- IM
- immunology 5
- IP
- isolation & purification 8
- ME
- metabolism 18
- PK
- pharmacokinetics 0
- PD
- pharmacology 0
- PH
- physiology 5
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 0
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 5
...
Occurrences in Medvik records
D
Chemicals and Drugs