Thalidomide [thalidomid]
topical
356
- Terms
-
Thalomid
-
Sedoval
Thalomid
Persistent link
https://www.medvik.cz/link/D013792
Definition
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
- DUI
- D013792 MeSH Browser
- CUI
- M0021267
- CAS
- 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-
Allowable subheadings
- AD
- administration & dosage 137
- AE
- adverse effects 95
- AG
- agonists 0
- AA
- analogs & derivatives 202
- AN
- analysis 1
- AI
- antagonists & inhibitors 4
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 2
- CH
- chemistry 2
- CL
- classification 0
- EC
- economics 1
- HI
- history 3
- IM
- immunology 4
- IP
- isolation & purification 0
- ME
- metabolism 0
- PK
- pharmacokinetics 16
- PD
- pharmacology 62
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 1
- TU
- therapeutic use 232
- TO
- toxicity 10
- UR
- urine 0
...
Occurrences in Medvik records