A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

DUI

D016222 MeSH Browser

CUI

M0024770

Previous indexing

Growth Substances (1974-1983); Fibroblast Growth Factor (1984-1990)

History note

2001(1991); for FIBROBLAST GROWTH FACTOR-2 use FIBROBLAST GROWTH FACTOR 2 (NM) 1995; for PROSTATROPIN use FIBROBLAST GROWTH FACTOR 2 (NM) 1986-2001

Public note

2001; FIBROBLAST GROWTH FACTOR-2 was indexed under FIBROBLAST GROWTH FACTOR, BASIC 1996-2001 & under FIBROBLAST GROWTH FACTOR 1995; PROSTATROPIN was indexed under NERVE TISSUE PROTEINS 1986-2001; CARTILAGE-DERIVED GROWTH FACTOR was indexed under PROTEINS 2005-2006