A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

Annotation

note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 is also available

DUI

D018435 MeSH Browser

CUI

M0027659

Previous indexing

Membrane Proteins (1980-1988); Glycoproteins (1980-1987); Membrane Glycoproteins (1989-1994)

History note

2019 (1999); use P-GLYCOPROTEIN 1995-1998

Public note

2019; see ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B 2018; see P-GLYCOPROTEIN 1995-1998; P-GLYCOPROTEIN was indexed under CARRIER PROTEINS & MEMBRANE GLYCOPROTEINS 1980-1994, GLYCOPROTEINS 1980-1987, and MEMBRANE PROTEINS 1980-1982