A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.

DUI

D050657 MeSH Browser

CUI

M0151835

Previous indexing

DNA-Binding Proteins (1987-2005); Transcription Factors (1987-2005); Neoplasm Proteins (1997-2005)

History note

2006(1987)

Public note

2006; POLYOMAVIRUS ENHANCER A BINDING PROTEIN 2 was indexed under DNA-BINDING PROTEINS & TRANSCRIPTION FACTORS 1987-2005, & under NEOPLASM PROTEINS 1997-2005; RUNT DOMAIN FACTOR was indexed under DNA-BINDING PROTEINS & TRANSCRIPTION FACTORS 2000-2005, & under NEOPLASM PROTEINS 2000-2005