Presenilins [preseniliny]

topical
6
Terms

presenilin

 

Presenilin

Persistent link   https://www.medvik.cz/link/D053763
Definition

Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.

DUI
D053763 MeSH Browser
CUI
M0496221
Previous indexing
Alzheimer Disease (1995-2006); Membrane Proteins (1995-2006)
History note
2007
Public note
2007

Allowable subheadings

AD
administration & dosage
AE
adverse effects 1
AG
agonists
AN
analysis 1
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 1
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics 3
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 3
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D01 Inorganic Chemicals 68
D02 Organic Chemicals 391
D03 Heterocyclic Compounds 191
D04 Polycyclic Compounds 65
D05 Macromolecular Substances 103
D06 Hormones, Hormone Substitutes, and Hormone Antagonists 43
D08 Enzymes and Coenzymes 7
D09 Carbohydrates 724
D10 Lipids 2 532
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 584
D12.776.543 Membrane Proteins 853
D12.776.543.019 5-Lipoxygenase-Activating Proteins 1
D12.776.543.029 Amphiregulin 3
D12.776.543.039 Amyloid beta-Protein Precursor 62
D12.776.543.080 Ankyrins 10
D12.776.543.090 Arrestins 6
D12.776.543.095 B7 Antigens 3
D12.776.543.100 Bacterial Outer Membrane Proteins 93
D12.776.543.116 Bcl-2-Like Protein 11 5
D12.776.543.131 Cadherin Related Proteins 1
D12.776.543.162 Calnexin 4
D12.776.543.178 Carbonic Anhydrase IX 20
D12.776.543.193 Chemokine CX3CL1 4
D12.776.543.200 Cornified Envelope Proline-Rich Proteins 2
D12.776.543.213 Discs Large Homolog 1 Protein
D12.776.543.219 Disks Large Homolog 4 Protein 1
D12.776.543.225 Dysferlin
D12.776.543.250 Dystrophin 46
D12.776.543.268 Dystrophin-Associated Proteins
D12.776.543.277 Electron Transport Chain Complex Proteins 31
D12.776.543.287 Ephrins 1
D12.776.543.306 gp100 Melanoma Antigen 1
D12.776.543.325 Heterotrimeric GTP-Binding Proteins 14
D12.776.543.475 LDL-Receptor Related Protein-Associated Protein
D12.776.543.484 Lipid-Linked Proteins 1
D12.776.543.488 MARVEL Domain-Containing Proteins 1
D12.776.543.493 Matrix Metalloproteinases, Membrane-Associated 1
D12.776.543.512 Membrane Fusion Proteins
D12.776.543.550 Membrane Glycoproteins 201
D12.776.543.585 Membrane Transport Proteins 208
D12.776.543.602 Mitochondrial Trifunctional Protein 2
D12.776.543.620 Myelin Proteins 32
D12.776.543.637 Myristoylated Alanine-Rich C Kinase Substrate
D12.776.543.653 NADPH Oxidases 44
D12.776.543.685 Neurofibromin 2 3
D12.776.543.689 Peroxisomal Biogenesis Factor 2
D12.776.543.693 Phospholipid Transfer Proteins 6
D12.776.543.695 Pore Forming Cytotoxic Proteins 8
D12.776.543.696 Presenilins 6
D12.776.543.696.500 Presenilin-1 12
D12.776.543.696.750 Presenilin-2 1
D12.776.543.697 Protoporphyrinogen Oxidase 5
D12.776.543.701 Pulmonary Surfactant-Associated Protein B 4
D12.776.543.717 Pulmonary Surfactant-Associated Protein C 5
D12.776.543.725 Receptor Activity-Modifying Proteins 1
D12.776.543.733 Receptor-Like Protein Tyrosine Phosphatases
D12.776.543.750 Receptors, Cell Surface 513
D12.776.543.800 Serrate-Jagged Proteins 1
D12.776.543.850 Spectrin 20
D12.776.543.875 Stromal Interaction Molecules 3
D12.776.543.900 Tetraspanins 13
D12.776.543.930 Thylakoid Membrane Proteins 1
D12.776.543.935 Thyroid Hormone-Binding Proteins
D12.776.543.940 Tight Junction Proteins 6
D12.776.543.985 Utrophin 1
D12.776.543.990 Vesicular Transport Proteins 46
D13 Nucleic Acids, Nucleotides, and Nucleosides 9
D20 Complex Mixtures 19
D23 Biological Factors 143
D25 Biomedical and Dental Materials 111
D26 Pharmaceutical Preparations 7 062
D27 Chemical Actions and Uses 374

Psn protein, Drosophila Chemical MeSH Browser

presenilin, Branchiostoma floridae Chemical MeSH Browser

presenilin-alpha protein, Xenopus Chemical MeSH Browser

presenilin-beta, protein, Xenopus Chemical MeSH Browser

Add

Narrower terms