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Autor
Albanes, Demetrios 1 Aldrich, Melinda C 1 Amos, Christopher I 1 Andrew, Angeline 1 Arnold, Susanne 1 Bickeböller, Heike 1 Bojesen, Stig Egil 1 Bolca, Ciprian 1 Brennan, Paul 1 Brunnström, Hans 1 Byun, Jinyoung 1 Caporaso, Neil 1 Chen, Chu 1 Christiani, David 1 Dai, Juncheng 1 Davies, Michael 1 Doherty, Jennifer 1 Duell, Eric 1 Fernandez-Somoano, Ana 1 Fernandez-Tardon, Guillermo 1
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Pracoviště
2nd Faculty of Medicine Institute of ... 1 Biomedical Data Science Geisel School... 1 British Columbia Cancer Agency Vancou... 1 Clalit National Cancer Control Center... 1 Clinical Center of Serbia Belgrade 11... 1 Copenhagen General Population Study H... 1 Department of Cancer Epidemiology H L... 1 Department of Clinical Sciences Malmö... 1 Department of Environmental Epidemiol... 1 Department of Environmental Health Ha... 1 Department of Epidemiology The Univer... 1 Department of Epidemiology University... 1 Department of Epidemiology University... 1 Department of Epidemiology and Biosta... 1 Department of Genetic Epidemiology Un... 1 Department of Medical Biosciences Ume... 1 Department of Oncology University of ... 1 Department of Pathology National Tube... 1 Department of Pharmaceutical Sciences... 1 Department of Preventive Medicine Seo... 1
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Autor
Albanes, Demetrios 1 Aldrich, Melinda C 1 Amos, Christopher I 1 Andrew, Angeline 1 Arnold, Susanne 1 Bickeböller, Heike 1 Bojesen, Stig Egil 1 Bolca, Ciprian 1 Brennan, Paul 1 Brunnström, Hans 1 Byun, Jinyoung 1 Caporaso, Neil 1 Chen, Chu 1 Christiani, David 1 Dai, Juncheng 1 Davies, Michael 1 Doherty, Jennifer 1 Duell, Eric 1 Fernandez-Somoano, Ana 1 Fernandez-Tardon, Guillermo 1
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Pracoviště
2nd Faculty of Medicine Institute of ... 1 Biomedical Data Science Geisel School... 1 British Columbia Cancer Agency Vancou... 1 Clalit National Cancer Control Center... 1 Clinical Center of Serbia Belgrade 11... 1 Copenhagen General Population Study H... 1 Department of Cancer Epidemiology H L... 1 Department of Clinical Sciences Malmö... 1 Department of Environmental Epidemiol... 1 Department of Environmental Health Ha... 1 Department of Epidemiology The Univer... 1 Department of Epidemiology University... 1 Department of Epidemiology University... 1 Department of Epidemiology and Biosta... 1 Department of Genetic Epidemiology Un... 1 Department of Medical Biosciences Ume... 1 Department of Oncology University of ... 1 Department of Pathology National Tube... 1 Department of Pharmaceutical Sciences... 1 Department of Preventive Medicine Seo... 1
- Formát
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Free Medical Journals od 2010
Nature Open Access od 2010-12-01
PubMed Central od 2012
Europe PubMed Central od 2012
ProQuest Central od 2010-01-01
Open Access Digital Library od 2015-01-01
Open Access Digital Library od 2015-01-01
Medline Complete (EBSCOhost) od 2012-11-01
Health & Medicine (ProQuest) od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources od 2010
PubMed
30254314
DOI
10.1038/s41467-018-05890-2
Knihovny.cz E-zdroje
Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In Asians, associations are driven by two independent HLA allele sets that both increase risk in HLA-DQB1*0401 and HLA-DRB1*0701; the latter better represented by the amino acid Ala-104. These results implicate several HLA-tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility.
- MeSH
- Asijci genetika MeSH
- běloši genetika MeSH
- frekvence genu MeSH
- genetická predispozice k nemoci etnologie genetika MeSH
- genotyp MeSH
- HLA antigeny genetika MeSH
- hlavní histokompatibilní komplex genetika MeSH
- jednonukleotidový polymorfismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mapování chromozomů * MeSH
- nádory plic etnologie genetika MeSH
- peptidy genetika MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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