Accumulating evidence indicates that immune checkpoint inhibitors (ICIs) can restore CD8+ cytotoxic T lymphocyte (CTL) functions in preclinical models of acute myeloid leukemia (AML). However, ICIs targeting programmed cell death 1 (PDCD1, best known as PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA4) have limited clinical efficacy in patients with AML. Natural killer (NK) cells are central players in AML-targeting immune responses. However, little is known on the relationship between co-inhibitory receptors expressed by NK cells and the ability of the latter to control AML. Here, we show that hepatitis A virus cellular receptor 2 (HAVCR2, best known as TIM-3) is highly expressed by NK cells from AML patients, correlating with improved functional licensing and superior effector functions. Altogether, our data indicate that NK cell frequency as well as TIM-3 expression levels constitute prognostically relevant biomarkers of active immunity against AML.
- Klíčová slova
- prevence, sexuální život, edukace, dotazníkový průzkum, adolescenti, dívky, edukace sestrou,
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- hygiena MeSH
- reprodukční zdraví MeSH
- rizikové faktory MeSH
- MeSH
- hospitalizovaní pacienti výchova MeSH
- lidé MeSH
- průzkumy a dotazníky MeSH
- statistika jako téma MeSH
- vzdělávání pacientů jako téma metody MeSH
- zdravotní sestry využití MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Slovenská republika MeSH
- Klíčová slova
- ošetřovatelská péče, vzdělávání sester,
- MeSH
- ošetřovatelský proces MeSH
- vnitřní lékařství MeSH
