Background: Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods: This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results: A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28-66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4-10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0-1, 22.7% for those who had scores of 2-3, 46.8% for those who had scores of 4-5, and 86.7% for those who have scores of 7-8. Conclusions: The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.
- MeSH
- břicho abnormality patofyziologie MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- logistické modely MeSH
- mortalita v nemocnicích MeSH
- prognóza * MeSH
- rizikové faktory MeSH
- rozdělení chí kvadrát MeSH
- senioři MeSH
- sepse diagnóza patofyziologie MeSH
- skóre závažnosti úrazu MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
Background: Acute appendicitis (AA) is the most common surgical disease, and appendectomy is the treatment of choice in the majority of cases. A correct diagnosis is key for decreasing the negative appendectomy rate. The management can become difficult in case of complicated appendicitis. The aim of this study is to describe the worldwide clinical and diagnostic work-up and management of AA in surgical departments. Methods: This prospective multicenter observational study was performed in 116 worldwide surgical departments from 44 countries over a 6-month period (April 1, 2016-September 30, 2016). All consecutive patients admitted to surgical departments with a clinical diagnosis of AA were included in the study. Results: A total of 4282 patients were enrolled in the POSAW study, 1928 (45%) women and 2354 (55%) men, with a median age of 29 years. Nine hundred and seven (21.2%) patients underwent an abdominal CT scan, 1856 (43.3%) patients an US, and 285 (6.7%) patients both CT scan and US. A total of 4097 (95.7%) patients underwent surgery; 1809 (42.2%) underwent open appendectomy and 2215 (51.7%) had laparoscopic appendectomy. One hundred eighty-five (4.3%) patients were managed conservatively. Major complications occurred in 199 patients (4.6%). The overall mortality rate was 0.28%. Conclusions: The results of the present study confirm the clinical value of imaging techniques and prognostic scores. Appendectomy remains the most effective treatment of acute appendicitis. Mortality rate is low.
- MeSH
- akutní nemoc terapie MeSH
- apendektomie škodlivé účinky metody normy MeSH
- apendicitida chirurgie MeSH
- délka pobytu statistika a číselné údaje MeSH
- dospělí MeSH
- hospitalizace statistika a číselné údaje MeSH
- laparoskopie metody statistika a číselné údaje MeSH
- lidé MeSH
- logistické modely MeSH
- počítačová rentgenová tomografie metody MeSH
- prospektivní studie MeSH
- rozdělení chí kvadrát MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
BACKGROUND: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. METHODS: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18-99) were enrolled in the WISS study. RESULTS: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2 %, a specificity of 83.5 % and a positive likelihood ratio of 5.4. CONCLUSIONS: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.
- Publikační typ
- časopisecké články MeSH
Cieľom operačnej liečby je dosiahnuť, pokiaľ možno maximálny kuratívny účinok liečby chorobného stavu. Napriek tomu značná časť operačnej liečby predstavuje paliatívnu liečbu. V oboch prípadoch sa však nutričná podpora v súčasnosti považuje za neoddeliteľnú súčasť komplexnej starostlivosti o chirurgického pacienta. Pre jej adekvátne použitie v klinickej praxi je nevyhnutné pochopiť základné patofyziologické procesy, mať schopnosť zhodnotiť nutričný status pacienta a identifikovať rizikové skupiny, správne načasovať a zvoliť druh, trvanie a zloženie nutričnej podpory pri zhodnotení rizík a možných komplikácií. Autori podávajú prehľad o problematike nutrície s ohľadom na niektoré špecifiká pacientov podstupujúcich operačnú liečbu.
The main goal of surgery is to achieve the most possible curative effect of the therapy for pathological conditions. Despite of that, a substantial part of surgical treatment represents palliative therapy. Nowadays in both cases nutritional support is considered as a substantial part of complex management of a surgical patient. To implicate nutritional support in clinical praxis lege artis, it is essential to understand basic pathophysiological processes, to be able to evaluate nutritional conditions of a patient, to identify risk groups, to set timing, type, duration and composition of nutritional support correctly including assessment of possible risk and complications. Authors try to bring a review of nutritional problems with respect to some specific issues of patients undergoing surgical therapy.
Divertikuly žalúdka sú veľmi zriedkavou patológiou. Zvyčajne sú asymptomatické a často sa zistia len náhodne, či už ako rádiologický, endoskopický alebo pitevný nález. Ich incidencia je nízka a vyskytujú sa rovnako často u mužov i žien. Bývajú lokalizované najmä na zadnej stene kardie alebo malej kurvatúre žalúdka. Autori predkladajú kazuistiku 58ročnej pacientky s ťažkou sideropenickou anémiou, výraznou stratou hmotnosti a neurčitými dyspeptickými ťažkosťami. Podozrenie na divertikul žalúdka vyjadril gastroenterológ pri gastrofibroskopii a potvrdil ho rádiológ dynamickým CT vyšetrením žalúdka. Divertikul bol lokalizovaný atypicky, tesne pod kardiou zo strany veľkej kurvatúry žalúdka. Pacientka bola operovaná. Pri konvenčnej laparotómii bola urobená resekcia divertikula lineárnym staplerom. Pooperačný priebeh bol bez komplikácií. Histologicky sa potvrdil nepravý divertikul. T. č. sa má pacientka dobre, od operácie pribrala 7 kg a krvný obraz má v norme.
Gastric diverticula represent a rare pathological condition. They are usually asymptomatic and are often found only by accident during radiologic or endoscopic examination, or during autopsy. Their incidence is low and evenly distributed between men and women. Gastric diverticula are most frequently located on the posterior wall of the cardia and on the lesser curvature of the stomach. The authors present a case study of a 58-year-old patient with severe sideropenic anaemia, a marked weight loss and non-specific dyspeptic symptoms. The suspicion of a diverticulum was raised by a gastroenterologist during gastrofibroscopy and confirmed by a radiologist following a dynamic CT examination of the stomach. The diverticulum had an atypical location beneath the cardia on the greater curvature. The patient was indicated for surgery. During conventional laparotomy, resection of the diverticulum was performed using a linear stapler. The postoperative course was uneventful. Histology confirmed a false diverticulum. The patient is doing well, is asymptomatic, has put on 7 kg since the operation and her blood count is normal.
- Klíčová slova
- divertikul žalúdka, odôvodnená indikácia chirurgickej liečby, laparoskopia, laparotómia,
- MeSH
- divertikulóza žaludku * diagnóza chirurgie MeSH
- laparoskopie * metody MeSH
- laparotomie * metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- příznaky a symptomy ústrojí trávicího MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- cholecystitida diagnóza komplikace MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- střevní píštěle diagnóza etiologie chirurgie MeSH
- žlučové kameny diagnóza chirurgie komplikace MeSH
- Check Tag
- lidé MeSH
- senioři nad 80 let MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
