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Autor: Loučka, Miloslav

34 záznamů v Medvik Filtry

Článek online

Quantitative ballistocardiography (Q-BCG) for measurement of cardiovascular dynamics

Physiological research. 2011 ; 60 (4) : 617-625.

Medvik
Zdroj

In the seventies of the past century ballistocardiography had been thought to be obsolete in cardiology for impossibility of objective calibration. In the present work the quantitative ballistocardiography (Q-BCG) for measurement of systolic force (F) and minute cardiac force (MF) in sitting subject was described. The new principle of piezoelectric transducer enabled to register the force caused by the heart and blood movement, which was not measured before. The calibration proved that the action of the force on the transducer was expressed quantitatively without the amplitude-, time-, and phase deformation. The close relationship of skeletal muscle force and F was proved. The F and MF changed under different physiological conditions (age, partial pressure of oxygen, body weight, skeletal muscle force). It was shown that the systolic force (F) and minute cardiac force (MF) are the physiological parameters neurohumorally regulated similarly as the heart rate or systolic volume.

Článek online

Dynamika zánětlivých markerů po nekomplikované implantaci bifurkačního stentgraftu do výdutě břišní aorty - porovnání se situací komplikovanou embolizací do viscerálních tepen
[Dynamics of the inflammatory markers after uncomplicated bifurcated stent graft implantation in abdominal aortic aneurysm - a comparison with the situation complicated by the embolization to the visceral arteries]

Česká radiologie. 2011 ; 65 (2) : 102-111.

Medvik
Zdroj

Cíl. Přibližně u 30% pacientů s aneuryzmatem aorty abdominální (AAA) léčených endovaskulárně je nutné extendovat stentgraft (SG) do jedné nebo obou a. iliaca externa (AIE). Zatím není dostatečně prozkoumáno, zda je to možné bez většího klinického rizika a jak intenzivní bude biochemická reakce. Metoda. Implantovali jsme bifurkační SG u 320 pacientů s AAA. Byli rozděleni do čtyř skupin podle perioperační okluze a. iliaca interna (All): skupina A (okluze pravé All), B (okluze levé All), C (okluze obou All) a skupina D (obě All průchodné). Ve všech skupinách jsme odebírali krevní vzorky v průběhu 7 pooperačních dní a měřili hladiny C-reaktivního proteinu (CRP), myoglobinu, laktátu a leukocytů. Sledovali jsme také příznaky ischémie kolon. Porovnali jsme vzestupy hladin laboratorních markerů mezi skupinami. Výsledky. Nejvyšší hladiny myoglobinu byly dosaženy 2. pooperační den; ve skupině A 224 ng/1, ve skupině B 261 ng/1 a ve skupině D 120 ng/1, zatímco ve skupině C byla naměřena hodnota 621 ng/1. Maximální hodnoty CRP byly dosaženy 3. pooperační den; ve skupině A 125 mg/l, ve skupině B 122 mg/l, ve skupině C 141 mg/l a ve skupině D 130 mg/l. Pouze u jednoho pacienta došlo k rozvoji ischemické kolitidy, která byla způsobena histologicky prokázanou mnohočetnou embolizací cholesterolových plátů. Závěr. Zvýšení hladin CRP, laktátu a leukocytů ve skupinách A, B a C nebylo statisticky významné ve srovnání se skupinou D. Myoglobin byl nejcitlivějším markerem subklinické dočasné ischémie po oboustranné okluzi All (skupina C).

Aim. In about 30% of patients with abdominal aortic aneurysm (AAA) it is necessary to extend bifurcated stent graft (SG) into external iliac arteries (EIA). It is unclear whether it can be done without clinical risk and how intensive will be the biochemical reaction. Method. We implanted bifurcated SG to 320 patients with AAA. They were divided into four groups according to perioperative IIA occlusion: group A (right IIA occluded); B (left IIA occluded); C (both IIA occluded) and group D (neither IIA occluded). In all groups we collected blood samples during 7 post-operative days and we investigated the values of C-reactive protein (CRP) , myoglobine, lactate and leucocytes. We also followed the symptoms of colonic ischemia. We compared the elevation of laboratory markers among the experimental groups. Results. The maximum myoglobin levels were reached on the 2nd post-operative day; in groups A, B and D the values were 224, 261 and 120 ng/1 resp., while in group C the value was 621 ng/ml. The maximum CRP levels were reached on the 3rd post-operative day; in groups A, B, C and D they were 125, 122, 141 and 130 mg/ml, resp. The only case of colonic ischemia was caused by multiple cholesterol plaque embolisation which was proved by histology. Conclusion. The elevations of CRP, lactate and leucocytes in groups A, B and C were not statistically different in comparison with group D. Myoglobin was the most sensitive marker of subclinical temporary ischemia after bilateral IIA occlusion (group C).

Článek online

New clearance evaluation method for hepatological diagnostics

Tichý, Josef A., 1929-2018
Autor Autorita
Loučka, Miloslav
Autor Autorita
Trefný, Zdeněk M., 1920-
Autor Autorita
Hojerová, Markéta
Autor Autorita
Svačinka, Jiří
Autor Autorita
Müller, Jindřich
Autor Autorita
Friedrichová, Michaela
Autor Autorita

Physiological research. 2009 ; 58 (2) : 287-292.

ISSN 0862-8408
Medvik
Zdroj

Pulse dye densitometry (PDD) enables the evaluation of hemodynamic state as well as liver function. A repeated examination, even after a short pause (or under stress condition), enables to follow safely the dynamics of liver pathology. From presented parameters we have evaluated as reliable the C5-clearance, an expression of equilibrium state in the two compartment liver system. Furthermore, T-index expresses ratio of C5 value to cardiac output, it is a sensitive indicator of the blood pole, i.e. sinusoidal uptake, which is in very good correlation with staging of hepatopathies. The isolated h constant in correlation to T-index is valuable For functional grading. The Japanese automatic analyzer of indocyanine green (ICG) dilution and elimination curves, after incorporation of a two compartment mathematical model, becomes more useful for complex hepatological diagnostics. Non-invasive PDD is becoming of uppermost importance to clinical interest, yielding comparable results as other complicated and invasive examinations and may be, therefore, repeated in short time intervals for different indications with minimal stress of examined patient.

Článek

Long-term survival of patients treated for Hodgkin's disease in 1971-1996 depending on the clinical stage of the disease, patient's fertility after therapy and cause of death analysis

Neoplasma. 2009 ; 56 (6) : 480-485.

ISSN 0028-2685
Medvik
Zdroj

The long-term survival in a group of 370 patients treated for Hodgkin's disease in the years 1971-1996 was retrospectively analyzed. Up to now 191 patients live. 179 patients have died. Since the year 1978 the uniform diagnostic and therapy protocol has been used. The therapy consisted in the combination of a radiation therapy (usual dose 40 Gy) with the COPP chemotherapy (6 cycles). Since the year 1988 the alternation of the ABVD and COPP chemotherapy has been used. According to the stage of the Hodgkin's disease and the patient's age the modification of the therapy was introduced. One chemotherapy cycle was removed for each 10 years above the 50 year age of the patient. The radiation therapy was not applied to the areas of the reproductive organs in young patients to preserve their fertility. The percentage of surviving patients for thirty years was 58.8% for Stage I and IIA,B and for Stage IIIA was 60.72%. In the group of surviving patients, we have registered 11 fathers and 34 females with up to 3 children. All together 75 children without health problems are monitored.