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Autor
Alfranca, Arantzazu 1 Andersson, Emma I 1 Cuesta-Mateos, Carlos 1 Espartero-Santos, Marina 1 Faber, Edgar 1 Fresno, Manuel 1 Fuentes, Patricia 1 Herling, Marco 1 Jungherz, Dennis 1 Juárez-Sánchez, Raquel 1 Kreutzman, Anna 1 Loscertales, Javier 1 Marcos-Jimenez, Ana 1 Mateu-Albero, Tamara 1 Mustjoki, Satu 1 Muñoz-Calleja, Cecilia 1 Oberbeck, Sebastian 1 Pérez-García, Yaiza 1 Schrader, Alexandra 1 Stamatakis, Kostantino 1
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Pracoviště
Department 1 of Internal Medicine Cen... 1 Department of Cell Biology and Immuno... 1 Department of Hemato Oncology Faculty... 1 Department of Hematology Hematology R... 1 Department of Hematology Hematology R... 1 Hematology Department Hospital Univer... 1 IMMED S L Immunological and Medicinal... 1 Immune System Development and Functio... 1 Immunology Department Hospital Univer... 1 Immunology Department Hospital Univer... 1 Immunology Department Hospital Univer... 1 Methodology Unit Hospital Universitar... 1
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Autor
Alfranca, Arantzazu 1 Andersson, Emma I 1 Cuesta-Mateos, Carlos 1 Espartero-Santos, Marina 1 Faber, Edgar 1 Fresno, Manuel 1 Fuentes, Patricia 1 Herling, Marco 1 Jungherz, Dennis 1 Juárez-Sánchez, Raquel 1 Kreutzman, Anna 1 Loscertales, Javier 1 Marcos-Jimenez, Ana 1 Mateu-Albero, Tamara 1 Mustjoki, Satu 1 Muñoz-Calleja, Cecilia 1 Oberbeck, Sebastian 1 Pérez-García, Yaiza 1 Schrader, Alexandra 1 Stamatakis, Kostantino 1
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Pracoviště
Department 1 of Internal Medicine Cen... 1 Department of Cell Biology and Immuno... 1 Department of Hemato Oncology Faculty... 1 Department of Hematology Hematology R... 1 Department of Hematology Hematology R... 1 Hematology Department Hospital Univer... 1 IMMED S L Immunological and Medicinal... 1 Immune System Development and Functio... 1 Immunology Department Hospital Univer... 1 Immunology Department Hospital Univer... 1 Immunology Department Hospital Univer... 1 Methodology Unit Hospital Universitar... 1
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- Cuesta-Mateos, Carlos
- Fuentes, Patricia
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Schrader, Alexandra
Autor Schrader, Alexandra Department I of Internal Medicine, Center for Integrated Oncology (CIO) Aachen-Bonn-Cologne-Duesseldorf (ABCD), Cologne Cluster of Excellence in Cellular Stress Response and Aging-Associated Diseases (CECAD), and Center of Molecular Medicine Cologne (CMMC), The University of Cologne, Cologne, Germany
- Juárez-Sánchez, Raquel
- Loscertales, Javier
- Mateu-Albero, Tamara
- Vega-Piris, Lorena
- Espartero-Santos, Marina
- Marcos-Jimenez, Ana
- Sánchez-López, Blanca Andrea
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Springer Nature OA/Free Journals od 2013-12-01
PubMed
33110606
DOI
10.1186/s40364-020-00234-z
Knihovny.cz E-zdroje
T-cell prolymphocytic leukemia (T-PLL) is a poor prognostic disease with very limited options of efficient therapies. Most patients are refractory to chemotherapies and despite high response rates after alemtuzumab, virtually all patients relapse. Therefore, there is an unmet medical need for novel therapies in T-PLL. As the chemokine receptor CCR7 is a molecule expressed in a wide range of malignancies and relevant in many tumor processes, the present study addressed the biologic role of this receptor in T-PLL. Furthermore, we elucidated the mechanisms of action mediated by an anti-CCR7 monoclonal antibody (mAb) and evaluated whether its anti-tumor activity would warrant development towards clinical applications in T-PLL. Our results demonstrate that CCR7 is a prognostic biomarker for overall survival in T-PLL patients and a functional receptor involved in the migration, invasion, and survival of leukemic cells. Targeting CCR7 with a mAb inhibited ligand-mediated signaling pathways and induced tumor cell killing in primary samples. In addition, directing antibodies against CCR7 was highly effective in T-cell leukemia xenograft models. Together, these findings make CCR7 an attractive molecule for novel mAb-based therapeutic applications in T-PLL, a disease where recent drug screen efforts and studies addressing new compounds have focused on chemotherapy or small molecules. Supplementary information: Supplementary information accompanies this paper at 10.1186/s40364-020-00234-z.
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