"IAA5011408"
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Purinergic P2X receptors represent a novel structural type of ligand-gated ion channels activated by extracellular ATP. So far, seven P2X receptor subunits have been found in excitable as well as non-excitable tissues. Little is known about their structure, mechanism of channel opening, localization, and role in the central nervous system. The aim of this work is to summarize recent investigations and describe our contribution to elucidating the structure of the ATP binding site and transmembrane domains of the P2X receptor, we also discuss the expression and physiological roles played by the ATP and P2X receptors in the anterior pituitary and hypothalamus.
- MeSH
- adenosintrifosfát metabolismus MeSH
- gonadotropní buňky metabolismus MeSH
- hypofýza metabolismus MeSH
- hypothalamus metabolismus MeSH
- ivermektin chemie farmakologie MeSH
- kvarterní struktura proteinů MeSH
- lidé MeSH
- molekulární modely MeSH
- neuroglie metabolismus MeSH
- neurony metabolismus MeSH
- purinergní receptory P2 chemie účinky léků metabolismus MeSH
- sekundární struktura proteinů MeSH
- terciární struktura proteinů MeSH
- vazba proteinů MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH