Purinergic P2X receptors represent a novel structural type of ligand-gated ion channels activated by extracellular ATP. So far, seven P2X receptor subunits have been found in excitable as well as non-excitable tissues. Little is known about their structure, mechanism of channel opening, localization, and role in the central nervous system. The aim of this work is to summarize recent investigations and describe our contribution to elucidating the structure of the ATP binding site and transmembrane domains of the P2X receptor, we also discuss the expression and physiological roles played by the ATP and P2X receptors in the anterior pituitary and hypothalamus.

• MeSH
• adenosintrifosfát metabolismus   MeSH
• gonadotropní buňky metabolismus   MeSH
• hypofýza metabolismus   MeSH
• hypothalamus metabolismus   MeSH
• ivermektin chemie   farmakologie   MeSH
• kvarterní struktura proteinů MeSH
• lidé MeSH
• molekulární modely MeSH
• neuroglie metabolismus   MeSH
• neurony metabolismus   MeSH
• purinergní receptory P2 chemie   účinky léků   metabolismus   MeSH
• sekundární struktura proteinů MeSH
• terciární struktura proteinů MeSH
• vazba proteinů MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH