Biochemical, functional and structural development of the nervous system*
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... ACID-BASE EQUILIBRIUM AND ITS MOST COMMON DISORDERS (Martin Vejrazka) 13 -- 1 Buffer systems 13 -- 1.1 ... ... Neurohumoral activation 84 -- 3.2.1 Role of adipokines 84 -- 3.2.2 Renin-angiotensin-aldosterone system ... ... 86 -- 3.2.3 Hyperactivation of sympathetic neuronal system (SNS) in MetS 87 -- 3.2.4 Myokines 88 -- ... ... 191 -- 2.5 Prion-like aggregates associated with physiological functions 192 -- X. ... ... system 230 -- 3 Alcohol abuse - a global problem 231 -- LIST OF ABBREVIATIONS 235 ...
Učební texty Univerzity Karlovy
First edition 241 stran : ilustrace ; 23 cm
- Konspekt
- Patologie. Klinická medicína
- Učební osnovy. Vyučovací předměty. Učebnice
- NLK Obory
- biochemie
- patologie
- NLK Publikační typ
- učebnice vysokých škol
... Shah -- 18.1 Structure and function 3933 -- 18.1.1 The upper respiratory tract 3933 -- Pallav L. ... ... Watts -- 19.1 Joints and connective tissue-structure and function 4379 -- Thomas Pap, Adelheid Korb-Pap ... ... Hay -- 23.1 Structure and function of skin 5591 -- John A. ... ... Rothwell) -- 24.10.2 Demyelinating disorders of the central nervous system 6026 -- Alasdair Coles and ... ... Turnbull -- 24.20 Developmental abnormalities ofthe central nervous system 6350 -- Chris M. ...
Sixth edition 4 svazky : ilustrace ; 29 cm
- MeSH
- vnitřní lékařství MeSH
- Publikační typ
- učebnice MeSH
- Konspekt
- Lékařské vědy. Lékařství
- NLK Obory
- vnitřní lékařství
- NLK Publikační typ
- kolektivní monografie
... CONTENTS -- Contributors, xix -- International System of Units and Prefixes for Physical Quantities, ... ... System, 495 -- Pinelopi Gkogkou, Sarah J. ... ... Burnet -- Introduction, 496 Tumour Types, 496 -- Anatomy of the Central Nervous System, 496 Anatomy of ... ... System Tumours, 555 -- Long-Term Effects of Radiotherapy for Central Nervous System Tumours, 555 Chemotherapy ... ... for Central Nervous System Tumours, 555 -- Low-Grade Astrocytoma, 555 High-Grade Astrocytoma, 557 Brainstem ...
Eighth edition xxiii, 615 stran : ilustrace, tabulky ; 28 cm
- MeSH
- nádory radioterapie MeSH
- nukleární lékařství metody MeSH
- radioterapie metody MeSH
- Publikační typ
- učebnice MeSH
- Konspekt
- Učební osnovy. Vyučovací předměty. Učebnice
- Lékařské vědy. Lékařství
- NLK Obory
- radiologie, nukleární medicína a zobrazovací metody
- onkologie
- NLK Publikační typ
- kolektivní monografie
... -- 5 Development, Function, and Pathology of the Placenta, 40 -- Emin Maltepe and Anna A. ... ... Gleason -- Part X: Respiratory System -- 42 Lung Development, 586 -- Erin Plosa and Susan H. ... ... -- 58 Central Nervous System Development, 852 -- Bobbi Fleiss, Helen Stolp, Valerie Mezger, and Pierre ... ... Gressens -- 59 Congenital Malformations of the Central Nervous System, 857 -- Sarah Bauer Huang and ... ... Bellus -- Part XX: Dermatologic Conditions -- 103 Newborn Skin Development: -- Structure and Function ...
Tenth edition xxvii, 1627stran : ilustrace ; 29 cm
- MeSH
- nemoci novorozenců MeSH
- neonatologie MeSH
- pediatrie MeSH
- perinatální péče MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Pediatrie
- NLK Obory
- pediatrie
- perinatologie a neonatologie
It has become apparent that the molecular and biochemical integrity of interactive families, genera, and species of human gut microflora is critically linked to maintaining complex metabolic and behavioral processes mediated by peripheral organ systems and central nervous system neuronal groupings. Relatively recent studies have established intrinsic ratios of enterotypes contained within the human microbiome across demographic subpopulations and have empirically linked significant alterations in the expression of bacterial enterotypes with the initiation and persistence of several major metabolic and psychiatric disorders. Accordingly, the goal of our review is to highlight potential thematic/functional linkages of pathophysiological alterations in gut microbiota and bidirectional gut-brain signaling pathways with special emphasis on the potential roles of gut dysbiosis on the pathophysiology of psychiatric illnesses. We provide critical discussion of putative thematic linkages of Parkinson's disease (PD) data sets to similar pathophysiological events as potential causative factors in the development and persistence of diverse psychiatric illnesses. Finally, we include a concise review of preclinical paradigms that involve immunologically-induced GI deficits and dysbiosis of maternal microflora that are functionally linked to impaired neurodevelopmental processes leading to affective behavioral syndromes in the offspring.
- MeSH
- duševní poruchy genetika patofyziologie MeSH
- dysbióza genetika MeSH
- lidé MeSH
- mikrobiota genetika MeSH
- mozek metabolismus patofyziologie MeSH
- Parkinsonova nemoc genetika patofyziologie MeSH
- střevní mikroflóra genetika MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
... , 93 Acid-Base Disorders, 95 -- Useful Websites, Tools/Calculators, and Apps, 96 -- 7 Clinical: Biochemical ... ... , Physical, and Functional Assessment, 98 -- Mary Demarest Litchford, PhD, RDN, LDN -- Biochemical Assessment ... ... Mazon, MS, RDN, CD -- Physiologic Development, 300 -- Nutrient Requirements, 301 -- Milk, 304 -- Food ... ... Foods, 360 Healthy Food and Water Systems and Sustainability, 363 Adult Health Next Steps, 363 Useful ... ... Karnik, MD, FACP, FCCP, FRCP -- The Pulmonary System, 681 Chronic Pulmonary Disease, 683 Asthma, 687 ...
14th edition xvii, 1134 stran : ilustrace, fotografie, tabulky ; 29 cm
- MeSH
- dietoterapie MeSH
- fyziologie výživy MeSH
- Publikační typ
- příručky MeSH
- Konspekt
- Fyziologie člověka a srovnávací fyziologie
- NLK Obory
- nutriční terapie, dietoterapie a výživa
- fyziologie
- NLK Publikační typ
- kolektivní monografie
... Development of Hyperbaric Oxygen Therapy 7 -- References 9 -- 2 Physical, Physiological, and Biochemical ... ... Effects of HBO 20 -- Effect of HBO on Enzymes 20 -- Effect of HBO on the Nervous System 20 -- Effect ... ... 41 -- Respiratory Function 41 -- Cardiovascular System 41 -- General Metabolic Effects 41 -- Effects ... ... 136 -- Skin 136 -- Gastrointestinal System 137 -- Effects on the Peripheral Nervous System 137 -- Effects ... ... on the Visual System 137 -- Effect on the Auditory System 137 -- Effect on the Central Nervous System ...
Sixth edition xlviii, 640 stran : ilustrace, tabulky ; 29 cm
- MeSH
- hyperbarická oxygenace MeSH
- oxygenoterapie MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- hyperbarická a letecká medicína
- NLK Publikační typ
- učebnice vysokých škol
... Functions of Synapses, and Neurotransmitters 577 -- General Design of the Nervous System 577 -- Major ... ... Levels of Central Nervous System Function 579 -- Comparison of the Nervous System to a Computer 580 ... ... Receptor and Neural Function of the Retina 647 -- Anatomy and Function of the Structural -- Elements ... ... System and the Adrenal Medulla 773 -- General Organization of the Autonomic Nervous System 773 -- Basic ... ... -- Neural Control of Gastrointestinal Function—Enteric Nervous System 799 -- Hormonal Control of Gastrointestinal ...
Thirteenth edition xix, 1145 stran : ilustrace (převážně barevné), grafy ; 29 cm
- MeSH
- fyziologické jevy MeSH
- Publikační typ
- učebnice MeSH
- Konspekt
- Fyziologie člověka a srovnávací fyziologie
- NLK Obory
- fyziologie
In mammals, excitatory synapses contain two major types of ionotropic glutamate receptors: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and N-methyl-d-aspartate receptors (NMDARs). Both receptor types are comprised of several subunits that are post-translationally modified by N-glycosylation. However, the precise N-glycans that are attached to these receptor types are largely unknown. Here, we used biochemistry to confirm that native NMDARs are extensively N-glycosylated; moreover, we found that the NMDAR GluN2B subunit differs from GluN1 subunits with respect to endoglycosidase H sensitivity. Next, we used a complete panel of lectins to determine the glycan composition of NMDARs in both cerebellar tissue and cultured cerebellar granule cells. Our experiments identified 23 lectins that pulled down both the GluN1 and GluN2B NMDAR subunits. We then performed an electrophysiological analysis using representative lectins and found that pre-incubating cerebellar granule cells with the AAL, WGA, or ConA alters the receptor's biophysical properties; this lectin-mediated effect was eliminated when the cells were deglycosylated with peptide-N-glycosidase F. Similar lectin-mediated effects were observed using HEK293 cells that express recombinant GluN1/GluN2B receptors. Finally, using mutant recombinant GluN subunits expressed in HEK293 cells, we found that 11 out of 12 predicted N-glycosylation sites in GluN1 and 7 out of 7 N-glycosylation sites in GluN2B are occupied by N-glycans. These data provide new insight into the role that N-glycosylation plays in regulating the function of NMDA receptors in the central nervous system. All animal experiments were performed in accordance with relevant institutional ethics guidelines and regulations with respect to protecting animal welfare. We examined the N-glycan composition of NMDA receptors (NMDARs) using deglycosylating enzymes, lectin-based biochemistry, and electrophysiology. Our results revealed that cerebellar NMDARs associate with 23 different lectins that have unique specificities for glycan structures. Furthermore, we found that 11 out of 12 predicted N-glycosylation sites in GluN1 and 7 out of 7 N-glycosylation sites in GluN2B are occupied by N-glycans. These data shed light on the glycan composition of NMDARs, revealing potential targets for the development of novel therapeutic approaches.
- MeSH
- elektrofyziologické jevy fyziologie MeSH
- HEK293 buňky MeSH
- krysa rodu rattus MeSH
- kyselina glutamová metabolismus MeSH
- lidé MeSH
- neurony metabolismus MeSH
- polysacharidy metabolismus MeSH
- receptory N-methyl-D-aspartátu metabolismus MeSH
- signální transdukce fyziologie MeSH
- synapse metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
... Doroshow, and Yves Pommier -- Classification, Biochemical, and -- Biologic Functions of Topoisomerases ... ... NEOPLASMS OFTHE CENTRAL NERVOUS SYSTEM -- 96. ... ... Molecular Biology of Central -- Nervous System Tumors 1403 -- Victoria Clark, and lennifer Moliterno ... ... Neoplasms of the Central Nervous System 1412 -- Susan M. Chang, Minesh P. Mehta, Michael A. ... ... Primary Central Nervous System Lymphoma 1597 -- Tracy T. ...
10th edition xlv, 2234 s. : il., tab. ; 28 cm
- MeSH
- lékařská onkologie metody trendy MeSH
- management bolesti MeSH
- management nemoci MeSH
- nádory diagnóza epidemiologie etiologie terapie MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- onkologie
- NLK Publikační typ
- kolektivní monografie
